| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:PDIC-NC
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| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:PDIC-NC
|
|
| | PDIC-NC Basic information |
| Product Name: | PDIC-NC | | Synonyms: | PDIC-NC;Anthra[2,1,9-def:6,5,10-d'e'f′]diisoquinoline-1,3,8,10(2H,9H)-tetrone, 5,6,12,13-tetrachloro-2,9-bis[2-(dimethylamino)ethyl]-, hydrochloride (1:2) | | CAS: | 2633013-75-7 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![PDIC-NC Structure]() |
| | PDIC-NC Chemical Properties |
| solubility | Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Methanol: Slightly soluble: 0.1-1 mg/ml |
| | PDIC-NC Usage And Synthesis |
| Description | PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.1,2 It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.1 PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).2 It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.WARNING This product is not for human or veterinary use. | | References | [1] XUEJIE ZHAO. Sulfonated Perylene as Three-in-One STING Agonist for Cancer Chemo-Immunotherapy[J]. Angewandte Chemie International Edition, 2024, 63 11. DOI: 10.1002/anie.202318799
[2] DR. ZHONGHUA LIU. Regulating Twisted Skeleton to Construct Organ-Specific Perylene for Intensive Cancer Chemotherapy[J]. Angewandte Chemie International Edition, 2021, 60 29: 16215-16223. DOI: 10.1002/anie.202105607 |
| | PDIC-NC Preparation Products And Raw materials |
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