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| | Ionizable Lipid 4 Basic information |
| | Ionizable Lipid 4 Chemical Properties |
| Boiling point | 764.891±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 0.961±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml | | pka | 10.044±0.25(predicted) |
| | Ionizable Lipid 4 Usage And Synthesis |
| Description | Ionizable lipid 4 is an ionizable cationic lipid (pKa = 6.1) and a hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5.1 Charge-altering lipid nanoparticles (CALNPs) containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing. LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model less effectively than CALNPs containing CA-lipid 5.WARNING This product is not for human or veterinary use. | | References | [1] YANG F, LEI L, WANG X, et al. Engineering Cell-selective Charge-altering Lipid Nanoparticles for Efficient siRNA Delivery in Vivo[J]. CCS Chemistry, 2023, 332 3. DOI: 10.31635/ccschem.023.202303542 |
| | Ionizable Lipid 4 Preparation Products And Raw materials |
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