|
|
| | DIMINAZENE ACETURATE Basic information |
| Product Name: | DIMINAZENE ACETURATE | | Synonyms: | CL218;Glycine, N-acetyl-, compd. with 4,4'-(1-triazene-1,3-diyl)bis[benzenecarboximidamide] (2:1);4,4’-(diamino)dibenzamidediaceturate;4,4’-(Diazoamino)dibenzamidinediaceturate;ganasag;ganaseg;glycine,n-acetyl-,compd.with4,4’-(1-triazene-1,3-diyl)bis(benzenecarboxim;glycine,n-acetyl-,compd.with4,4’-(1-triazene-1,3-diyl)bis[benzenecarboximid | | CAS: | 908-54-3 | | MF: | C22H29N9O6 | | MW: | 515.52 | | EINECS: | 212-999-2 | | Product Categories: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;BERENIL | | Mol File: | 908-54-3.mol |  |
| | DIMINAZENE ACETURATE Chemical Properties |
| Melting point | 202 °C | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | powder | | color | Orange to Dark Orange | | Water Solubility | Soluble to 100 mM in water | | Stability: | Stable. Incompatible with strong oxidizing agents. | | Major Application | forensics and toxicology
pharmaceutical (small molecule)
veterinary | | InChI | 1S/C14H15N7.2C4H7NO3/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18;2*1-3(6)5-2-4(7)8/h1-8H,(H3,15,16)(H3,17,18)(H,19,20);2*2H2,1H3,(H,5,6)(H,7,8) | | InChIKey | OKQSSSVVBOUMNZ-UHFFFAOYSA-N | | SMILES | CC(=O)NCC(O)=O.CC(=O)NCC(O)=O.NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1 | | CAS DataBase Reference | 908-54-3(CAS DataBase Reference) |
| WGK Germany | 3 | | RTECS | MB7605000 | | Storage Class | 11 - Combustible Solids |
| | DIMINAZENE ACETURATE Usage And Synthesis |
| Description | Diminazene is a diamidine that is cytotoxic to protozoa, including Trypanosoma, Babesia, and Cytauxzoon. Diamidines, including diminazene, affect a variety of enzymes and modulate interactions between nucleic acids and proteins. Diminazene inhibits diamine oxidase with a Ki value of 13 nM. In Trypanosoma, transport proteins are important in the effectiveness of diminazene. In rats and in vitro, diminazene enhances the enzymatic activity of angiotensin-converting enzyme 2. | | Chemical Properties | solid | | Uses | Diminazene aceturate is an anti-protozoal drug. Diminazene Diaceturate is used as an anti-trypanosomal agent. | | Uses | antiprotozoal as aceturate | | Uses | An anti-protozoal and anti-trypanosomal compound | | Definition | ChEBI: An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine. | | Veterinary Drugs and Treatments | Diminazene is used to treat trypanosomiasis in dogs and livestock
(sheep, goats, cattle), Babesia infections in dogs and horses, and cytauxzoonosis
in cats. The drug is not commercially available in the
USA, but is available and used in many countries. | | storage | Store at RT | | References | [1] J MOSQUEDA. Current advances in detection and treatment of babesiosis.[J]. Current medicinal chemistry, 2012, 19 10: 1504-1518. DOI: 10.2174/092986712799828355
[2] GEORGE LAYLSON DA SILVA OLIVEIRA Rivelilson M de F. Diminazene aceturate—An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics[J]. Pharmacological research, 2015, 102: Pages 138-157. DOI: 10.1016/j.phrs.2015.10.005
[3] TIEN L. HUANG Jean J V E Annie Mayence. Some non-conventional biomolecular targets for diamidines. A short survey[J]. Bioorganic & Medicinal Chemistry, 2014, 22 7: Pages 1983-1992. DOI: 10.1016/j.bmc.2014.02.049
[4] JANE C MUNDAY H P de K Luca Settimo. Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.[J]. Frontiers in Pharmacology, 2015, 6: 32. DOI: 10.3389/fphar.2015.00032
[5] VINAYAK SHENOY. Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.[J]. American journal of respiratory and critical care medicine, 2013, 187 6: 648-657. DOI: 10.1164/rccm.201205-0880oc |
| | DIMINAZENE ACETURATE Preparation Products And Raw materials |
|