- Fmoc-Glu(OtBu)-OH
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- $0.00 / 25kg
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2026-04-30
- CAS:71989-18-9
- Min. Order: 1kg
- Purity: 98%min
- Supply Ability: 1000kg
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| | Fmoc-L-glutamic acid 5-tert-butyl ester Basic information |
| | Fmoc-L-glutamic acid 5-tert-butyl ester Chemical Properties |
| Melting point | 83-90 °C | | alpha | -4.5 º (c=1, 80% acetic acid) | | Boiling point | 633.5±55.0 °C(Predicted) | | density | 1.232±0.06 g/cm3(Predicted) | | refractive index | -4 ° (C=1, 80% AcOH) | | storage temp. | Store below +30°C. | | solubility | soluble in Methanol | | pka | 3.70±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | Optical Rotation | [α]20/D 5.0±2.0°, c = 1% in acetic acid: water (4:1) | | BRN | 3636375 | | Major Application | peptide synthesis | | InChIKey | OTKXCALUHMPIGM-FQEVSTJZSA-N | | SMILES | C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | | CAS DataBase Reference | 71989-18-9(CAS DataBase Reference) |
| | Fmoc-L-glutamic acid 5-tert-butyl ester Usage And Synthesis |
| Description | Fmoc-L-glutamic acid 5-tert-butyl ester is a Fmoc derivative with an N-substituted tert-butyl ester molecule. It is white or gray-white solid crystals at room temperature and pressure, poor solubility in water and insoluble in petroleum ether, but soluble in ethyl acetate, acetic acid and N,N-dimethylformamide. | | Chemical Properties | White powder | | Uses |
Fmoc-Glu(OtBu)-OH (Fmoc-L-glutamic acid 5-tert-butyl ester) can be employed as a:
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Ligand in the synthesis of cis-substituted cyclopropane carboxylic acids via C-H activation of cyclopropane carboxamides using Pd catalyst.
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Linker in the preparation of multi-small molecule-conjugated PTX (paclitaxel) derivatives.
It can be also used as a building block in the preparation of stapled α-helical peptides , and peptide C-terminal thioesters .
| | General Description |
Fmoc-L-glutamic acid 5-tert-butyl ester is a protected building block used for the introduction of glutamic acid into peptides.
| | reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| | Fmoc-L-glutamic acid 5-tert-butyl ester Preparation Products And Raw materials |
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