| Company Name: |
China DongFan Chemical Co.,LTD
|
| Tel: |
86-0571-85151182 |
| Email: |
|
| Products Intro: |
Product Name:2-(3,4-difluorophenyl)oxirane
CAS:111991-13-0
Purity:98% HPLC Package:10g:50g;100g;250g
|
| Company Name: |
Shanghai Balmxy Pharmaceutical Co., Ltd
|
| Tel: |
021-24206007 13764915196 |
| Email: |
sales@balmxy.com |
| Products Intro: |
Product Name:2-(3,4-Difluorophenyl)oxirane
CAS:111991-13-0
Purity:98%+ Package:5g;25g;100g;500g;1kg;5kg;25kg;100kg Remarks:BX30024
|
|
| | 2-(3,4-difluorophenyl)oxirane Basic information |
| Product Name: | 2-(3,4-difluorophenyl)oxirane | | Synonyms: | 2-(3,4-difluorophenyl)oxirane;(3,4-Difluorophenyl)oxirane;Ticagrelor Impurity 101;Oxirane, (3,4-difluorophenyl)-;Oxirane, 2-(3,4-difluorophenyl)- | | CAS: | 111991-13-0 | | MF: | C8H6F2O | | MW: | 156.13 | | EINECS: | | | Product Categories: | | | Mol File: | 111991-13-0.mol |  |
| | 2-(3,4-difluorophenyl)oxirane Chemical Properties |
| Boiling point | 186.8±40.0 °C(Predicted) | | density | 1.335±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | 2-(3,4-difluorophenyl)oxirane Usage And Synthesis |
| Synthesis | Under nitrogen protection, 14 g (100 mmol) of 3,4-difluorostyrene was dissolved in tetrahydrofuran. A 30% hydrogen peroxide solution (300 mmol) was slowly added dropwise at 20 °C, keeping the reaction temperature constant with continuous stirring for 4 hours. After completion of the reaction, water was added to the reaction mixture for stratification. The organic layer was separated and washed with appropriate amount of water. Subsequently, the organic layer was concentrated under reduced pressure and finally purified by column chromatography to afford 7.3 g of 2-(3,4-difluorophenyl)oxirane in 46.7% yield and 19.43% enantiomeric excess (ee) value. | | References | [1] Patent: CN106631887, 2017, A. Location in patent: Paragraph 0034-0035 |
| | 2-(3,4-difluorophenyl)oxirane Preparation Products And Raw materials |
|