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5-Hydroxyisoquinoline

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CAS:2439-04-5
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CAS:2439-04-5
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CAS:2439-04-5
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-02038
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  • 2026-04-17
  • CAS:2439-04-5
  • Min. Order: 1KG
  • Purity: 98%min
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  • 2025-12-24
  • CAS:2439-04-5
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  • Purity: 99.0%
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5-Hydroxyisoquinoline Basic information
Product Name:5-Hydroxyisoquinoline
Synonyms:5-HYDROXYISOQUINOLINE;5-ISOQUINOLINOL;5-Hydroxyisoquinolne;ISOQUINOLIN-5-OL;5-HYDROXYISOQUINOLINE, TECH., 90%;5-Hydroxyisoquinoline,tech.90%;5-Hydroxyisoquinoline 90%;5-Hydroxyisoquinoline90%
CAS:2439-04-5
MF:C9H7NO
MW:145.16
EINECS:219-456-9
Product Categories:Quinolines;Heterocyclic Series;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:2439-04-5.mol
5-Hydroxyisoquinoline Structure
5-Hydroxyisoquinoline Chemical Properties
Melting point 213-215
Boiling point 264.27°C (rough estimate)
density 1.1555 (rough estimate)
refractive index 1.4500 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Granular Powder
pka8.53±0.40(Predicted)
color Beige
InChIInChI=1S/C9H7NO/c11-9-3-1-2-7-6-10-5-4-8(7)9/h1-6,11H
InChIKeyCSNXUYRHPXGSJD-UHFFFAOYSA-N
SMILESC1C2=C(C(O)=CC=C2)C=CN=1
CAS DataBase Reference2439-04-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-21/22
Safety Statements 26-37/39-36/37/39-36
WGK Germany 3
Hazard Note Irritant
HS Code 29334900
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
5-Hydroxyisoquinoline Usage And Synthesis
Chemical Propertiesbeige granular powder
Uses5-Hydroxyisoquinoline is a reagent used in the preparation of PARP inhibitor.
Synthesis
5-Isoquinolinesulfonic acid

27655-40-9

5-Hydroxyisoquinoline

2439-04-5

The general procedure for the synthesis of 5-hydroxyisoquinoline from 5-isoquinolinesulfonic acid is as follows: 23 g of 5-isoquinolinesulfonic acid is added to 400 ml of water, followed by 60 g of sodium hydroxide. The reaction mixture was heated to reflux and stirred continuously under this condition for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with dilute hydrochloric acid to 5. Then, ethyl acetate was added for extraction and the organic phase was separated and collected. The organic phase was concentrated and the resulting residue was purified by silica gel column chromatography to yield 16 g of 5-hydroxyisoquinoline.

References[1] Acta Poloniae Pharmaceutica, 1994, vol. 51, # 6, p. 479 - 482
[2] Patent: CN107778231, 2018, A. Location in patent: Paragraph 0023; 0024
Tag:5-Hydroxyisoquinoline(2439-04-5) Related Product Information
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