- 5-Hydroxyisoquinoline
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- $0.00 / 1KG
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2025-11-29
- CAS:2439-04-5
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- 5-Hydroxyisoquinoline
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- $1.10 / 1g
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2025-11-18
- CAS:2439-04-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
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| | 5-Hydroxyisoquinoline Basic information |
| | 5-Hydroxyisoquinoline Chemical Properties |
| Melting point | 213-215 | | Boiling point | 264.27°C (rough estimate) | | density | 1.1555 (rough estimate) | | refractive index | 1.4500 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Granular Powder | | pka | 8.53±0.40(Predicted) | | color | Beige | | InChI | InChI=1S/C9H7NO/c11-9-3-1-2-7-6-10-5-4-8(7)9/h1-6,11H | | InChIKey | CSNXUYRHPXGSJD-UHFFFAOYSA-N | | SMILES | C1C2=C(C(O)=CC=C2)C=CN=1 | | CAS DataBase Reference | 2439-04-5(CAS DataBase Reference) |
| | 5-Hydroxyisoquinoline Usage And Synthesis |
| Chemical Properties | beige granular powder | | Uses | 5-Hydroxyisoquinoline is a reagent used in the preparation of PARP inhibitor. | | Synthesis | The general procedure for the synthesis of 5-hydroxyisoquinoline from 5-isoquinolinesulfonic acid is as follows: 23 g of 5-isoquinolinesulfonic acid is added to 400 ml of water, followed by 60 g of sodium hydroxide. The reaction mixture was heated to reflux and stirred continuously under this condition for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with dilute hydrochloric acid to 5. Then, ethyl acetate was added for extraction and the organic phase was separated and collected. The organic phase was concentrated and the resulting residue was purified by silica gel column chromatography to yield 16 g of 5-hydroxyisoquinoline. | | References | [1] Acta Poloniae Pharmaceutica, 1994, vol. 51, # 6, p. 479 - 482
[2] Patent: CN107778231, 2018, A. Location in patent: Paragraph 0023; 0024 |
| | 5-Hydroxyisoquinoline Preparation Products And Raw materials |
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