- 3-Amino-5-methylpyrazole
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- $0.00 / 1KG
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2026-02-03
- CAS:31230-17-8
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- 3-Amino-5-methylpyrazole
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- $1.10 / 1g
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2025-11-18
- CAS:31230-17-8
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | 3-Amino-5-methylpyrazole Basic information |
| | 3-Amino-5-methylpyrazole Chemical Properties |
| Melting point | 45-47 °C (lit.) | | Boiling point | 213 °C/14 mmHg (lit.) | | density | 1.0548 (rough estimate) | | refractive index | 1.5200 (estimate) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in Dichloromethane and Methanol. | | pka | 15.84±0.10(Predicted) | | form | Solid | | color | Light yellow to orange | | Sensitive | Air Sensitive | | BRN | 1904 | | Stability: | Light Sensitive | | InChI | 1S/C4H7N3/c1-3-2-4(5)7-6-3/h2H,1H3,(H3,5,6,7) | | InChIKey | FYTLHYRDGXRYEY-UHFFFAOYSA-N | | SMILES | Cc1cc(N)n[nH]1 | | CAS DataBase Reference | 31230-17-8(CAS DataBase Reference) | | EPA Substance Registry System | 1H-Pyrazol-3-amine, 5-methyl- (31230-17-8) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29331990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-Amino-5-methylpyrazole Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | 3-Amino-5-methyl-1H-pyrazole was employed as beta-sheet template to investigate its interaction with ferrocenoyl-dipeptides. It is also used in the synthesis of 4-aryl-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo[3,4-b]quinolin-5-ones. It can react with 4-Ethoxymethylene-2-phenyl-4H-oxazol-5-one to get N-(2-Methyl-7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-6-yl)-benzamide. | | Uses | 3-Amino-5-methylpyrazole was employed as beta-sheet template to investigate its interaction with ferrocenoyl-dipeptides. It was also used in the synthesis of 4-aryl-3,7,7-trimethyl-2,4,6,7,8,9-hexahydropyrazolo[3,4-b]quinolin-5-ones. | | Definition | ChEBI: 5-Methyl-3-pyrazolamine is a heterocyclic compound and a dicarboximide. | | General Description | Complexation of the amino- and carboxyl-protected tripeptide with 3-amino-5-methylpyrazole was studied by low-temperature NMR experiments in a freonic solvent. | | Synthesis | General procedure for the synthesis of 3-amino-5-methyl-1H-pyrazole from 3-aminobut-2-enenenitrile: 10 g of 3-aminobut-2-enenitrile and 5 L of ethanol were added to a 10 L reaction flask and stirred until completely dissolved. Subsequently, 2500 g of 80% hydrazine hydrate was added. After stirring at room temperature for 10-20 minutes, the reaction was slowly heated to reflux, keeping the reaction temperature between 85-95 °C. Note: A large amount of gas is generated during the reaction. When the reaction has been carried out for 1.5-2.5 hours, confirm the complete reaction of the feedstock by TLC monitoring. Upon completion of the reaction, the reaction solution is concentrated under reduced pressure at 50-60°C to 20-30% of the original volume. Finally, a light yellow liquid (converted to a light yellow solid after cooling) was obtained by oil pump distillation in a yield of 2230 g with 94.2% yield. The purity of 3-amino-5-methyl-1H-pyrazole was higher than 98% and the content of single impurity was lower than 0.5% by GC and HPLC analysis. | | References | [1] Patent: CN108341782, 2018, A. Location in patent: Paragraph 0018; 0019; 0021; 0022
[2] Patent: CN104844567, 2017, B. Location in patent: Paragraph 0031; 0034; 0039; 0044 |
| | 3-Amino-5-methylpyrazole Preparation Products And Raw materials |
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