- 4-BROMOPYRIDIN-2-OL
-
- $0.00 / 25kg
-
2025-12-01
- CAS:36953-37-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 4-BROMOPYRIDIN-2-OL
-
- $1.10 / 1g
-
2025-11-18
- CAS:36953-37-4
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 4-BROMOPYRIDIN-2-OL
-
- $10.00 / 1kg
-
2025-05-23
- CAS:36953-37-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 ton
|
| | 4-BROMOPYRIDIN-2-OL Basic information |
| | 4-BROMOPYRIDIN-2-OL Chemical Properties |
| Melting point | 186 °C | | Boiling point | 305.9±42.0 °C(Predicted) | | density | 1.776±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Crystalline Powder | | pka | 10.54±0.10(Predicted) | | color | White | | InChI | InChI=1S/C5H4BrNO/c6-4-1-2-7-5(8)3-4/h1-3H,(H,7,8) | | InChIKey | SSLMGOKTIUIZLY-UHFFFAOYSA-N | | SMILES | C1(=O)NC=CC(Br)=C1 | | CAS DataBase Reference | 36953-37-4(CAS DataBase Reference) |
| Risk Statements | 36/38 | | Safety Statements | 36 | | Hazard Note | Harmful | | HS Code | 29333990 |
| | 4-BROMOPYRIDIN-2-OL Usage And Synthesis |
| Uses | 4-Bromo-2-hydroxypyridine is used as a reagent to synthesize trans-3,4’-bispyridinylethylenes, compounds that act as inhibitors of protein kinase B that are used to treat cancer. | | Synthesis | General procedure for the synthesis of 4-bromo-2-hydroxypyridine from 4-bromo-2-methoxypyridine:
Step a: Preparation of 4-bromopyridin-2(1H)-one; To a solution of 1,4-dioxane (26 mL) of 4-bromo-2-methoxypyridine (1.0 g, 5.3 mmol) was added an aqueous 4M HCl solution (13 mL). The reaction mixture was heated at 90 °C for 5 h, followed by heating at 50 °C overnight. Upon completion of the reaction, it was neutralized to pH 8-9 with 1N NaOH solution and extracted with ethyl acetate. The organic phase was dried with anhydrous MgSO4 and concentrated to give 4-bromopyridin-2(1H)-one as a white solid (490 mg, 53% yield). The aqueous phase was concentrated and the residue was stirred with dichloromethane and filtered. The filtrate was concentrated to give additional 4-bromopyridin-2(1H)-one (320 mg, 35% yield).ESI-MS m/z calculated value 173.0, measured value 174.3 (M+1)+. Retention time 0.32 min. 1H NMR (400 MHz, DMSO-d6) δ 11.87 (s, 1H), 7.36 (d, J=7.0 Hz, 1H), 6.64 (d, J=2.0 Hz, 1H), 6.37 (dd, J=2.0,7.0 Hz, 1H). | | References | [1] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 97
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 21, p. 6262 - 6267 |
| | 4-BROMOPYRIDIN-2-OL Preparation Products And Raw materials |
|