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| | 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Basic information |
| Product Name: | 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile | | Synonyms: | 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile;5-Amino-4-cyano-1-(2-pyridyl)pyrazole;5-Amino-1-(2-pyridyl)pyrazole-4-carbonitrile;5-Amino-1-(pyridin-2-yl);1H-Pyrazole-4-carbonitrile, 5-amino-1-(2-pyridinyl)-;5-amino-1-pyridin-2-ylpyrazole-4-carbonitrile | | CAS: | 72816-14-9 | | MF: | C9H7N5 | | MW: | 185.19 | | EINECS: | | | Product Categories: | | | Mol File: | 72816-14-9.mol |  |
| | 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Chemical Properties |
| density | 1.37 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Appearance | Light brown to brown Solid |
| | 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Usage And Synthesis |
| Synthesis | To 2-hydrazinopyridine (3.00 g, 27.5 mmol) and ethoxymethylene malononitrile (3.37 g, 27.5 mmol) in 50 mL of ethanol, triethylamine (3.8 mL, 27.5 mmol) was added. The reaction mixture was heated to reflux for about 3.5 hours. After completion of the reaction, it was cooled to room temperature and the precipitated solid was collected to afford the white solid product 5-amino-1-(2-pyridyl)-1H-pyrazole-4-carbonitrile (4.33 g, 85% yield). The product was characterized by 1H NMR (DMSO-d6): δ 8.46 (dd, 1H), 8.11 (brs, 2H), 8.01 (m, 1H), 7.88 (s, 1H), 7.84 (d, 1H), 7.35 (m, 1H) ppm. | | References | [1] Patent: WO2004/9597, 2004, A2. Location in patent: Page 21
[2] European Journal of Organic Chemistry, 2018, vol. 2018, # 13, p. 1514 - 1524
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2121 - 2125
[4] Organic and Biomolecular Chemistry, 2007, vol. 5, # 17, p. 2758 - 2761
[5] Patent: US2007/161662, 2007, A1 |
| | 5-amino-1-(pyridin-2-yl)-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials |
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