- Iodoacetonitrile
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- $15.00 / 1KG
-
2021-07-13
- CAS:624-75-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Iodoacetonitrile
-
- $15.00 / 1KG
-
2021-07-10
- CAS:624-75-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Iodoacetonitrile
-
- $1.00 / 1g
-
2020-01-10
- CAS:624-75-9
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 10000KGS
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| | Iodoacetonitrile Basic information |
| | Iodoacetonitrile Chemical Properties |
| Boiling point | 182-184 °C/720 mmHg (lit.) | | density | 2.307 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.574(lit.) | | RTECS | AM0740000 | | Fp | 187 °F | | storage temp. | 2-8°C | | solubility | Chloroform, Methanol (Slightly) | | form | Liquid | | Specific Gravity | 2.307 | | color | Clear red to brown | | Water Solubility | Soluble in benzene, alcohol, acetone, ether. Slightly soluble in water. Insoluble in hexane. | | Sensitive | Light Sensitive | | BRN | 1734628 | | Exposure limits | NIOSH: IDLH 25 mg/m3 | | Stability: | Light Sensitive | | CAS DataBase Reference | 624-75-9(CAS DataBase Reference) | | NIST Chemistry Reference | Iodoacetonitrile(624-75-9) | | EPA Substance Registry System | Acetonitrile, iodo- (624-75-9) |
| | Iodoacetonitrile Usage And Synthesis |
| Chemical Properties | clear red to brown liquid | | Uses | Iodoacetonitrile is used for alkylation of nucleophiles. It undergoes Reformatsky and Wittig-type reactions with aldehydes. | | Synthesis | Step 2. The method followed the synthesis of literature S5: 2,6-piperidinedimethanol (3.80 g, 26.21 mmol), iodoacetonitrile (5.24 g, 31.45 mmol), triethylamine (Et3N, 4.38 mL, 31.45 mmol) and anhydrous N,N-dimethylformamide (DMF, 20 mL) were added to the reaction system. Upon completion of the reaction, the product was purified by fast column chromatography using a solvent mixture of dichloromethane (CH2Cl2) and methanol (CH3OH) (9:1, v/v) as eluent to afford iodoacetonitrile as a straw-colored oily substance (2.5 g, 53% yield). the molecular ion peak m/z (M + H)+ was determined by FAB MS to be 185. iodoacetonitrile was prepared using the Finkelstein reaction: Bromoacetonitrile (BrCH2CN, 3.77 g, 0.0314 mmol) was added dropwise to an acetone solution of sodium iodide (NaI, 4.71 g, 0.031 mmol) under stirring. A precipitate of sodium bromide (NaBr) was produced within a few minutes of the reaction, indicating that a halogen exchange reaction had occurred. The sodium bromide was removed by filtration and the acetone was subsequently evaporated under vacuum to give the crude product iodoacetonitrile (5.24 g, 100% yield). | | References | [1] Patent: WO2005/61453, 2005, A1. Location in patent: Page/Page column 15
[2] Journal of the American Chemical Society, 1980, vol. 102, # 4, p. 1367 - 1371 |
| | Iodoacetonitrile Preparation Products And Raw materials |
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