3-Nitrosalicylaldehyde manufacturers
- 3-Nitrosalicylaldehyde
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- $0.00 / 1g
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2026-01-05
- CAS:5274-70-4
- Min. Order: 10mg
- Purity: 99%HPLC
- Supply Ability: 2000tons
- 3-Nitrosalicylaldehyde
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- $1.00 / 1ASSAYS
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2019-07-10
- CAS:5274-70-4
- Min. Order: 1ASSAYS
- Purity: 98%
- Supply Ability: 1kg,2kg,100kg
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| | 3-Nitrosalicylaldehyde Basic information |
| | 3-Nitrosalicylaldehyde Chemical Properties |
| Melting point | 105-109 °C(lit.) | | Boiling point | 295.67°C (rough estimate) | | density | 1.5216 (rough estimate) | | refractive index | 1.6280 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 5.07±0.24(Predicted) | | form | Crystalline Powder | | color | Yellow to brown | | Water Solubility | slightly soluble | | Sensitive | Air Sensitive | | InChI | 1S/C7H5NO4/c9-4-5-2-1-3-6(7(5)10)8(11)12/h1-4,10H | | InChIKey | NUGOTBXFVWXVTE-UHFFFAOYSA-N | | SMILES | Oc1c(C=O)cccc1[N+]([O-])=O | | CAS DataBase Reference | 5274-70-4(CAS DataBase Reference) | | NIST Chemistry Reference | Benzaldehyde, 2-hydroxy-3-nitro-(5274-70-4) | | EPA Substance Registry System | Benzaldehyde, 2-hydroxy-3-nitro- (5274-70-4) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22-20/21/22 | | Safety Statements | 26-36-36/37/39 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 29130000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 3-Nitrosalicylaldehyde Usage And Synthesis |
| Chemical Properties | yellow to brown crystalline powder | | Uses | 2-Hydroxy-3-nitrobenzaldehyde may be used in the synthesis of 5-acetyl-4-aryl-6-methyl-1,2,3,4-tetrahydro pyrimidine. | | General Description | 2-Hydroxy-3-nitrobenzaldehyde can be extracted from the leaves of Actephila merrilliana. Its molecule is planar. On reaction with dapsone, it affords a colorless solution. | | Synthesis | GENERAL METHOD: Salicylaldehyde (10 mmol) was mixed with urea nitrate (10 mmol) in acetonitrile-water solvent mixture (95:5, 5 ml, v/v) in a 25 ml round bottom flask. The reaction mixture was placed in a Milestone Start SYNTH microwave reactor and heated at 80°C for 40-50 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature, quenched with water and extracted with dichloromethane. The organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford the target product 3-nitrosalicylaldehyde. In all experiments, o-nitrosalicylaldehyde was selectively generated and no para-nitro-substituted by-products were detected. The resulting compounds were characterized by 1H NMR, 13C NMR, melting point determination (for solid samples), GC-MS analysis and comparison with standards. | | References | [1] Chinese Chemical Letters, 2010, vol. 21, # 4, p. 403 - 406
[2] Synthetic Communications, 2011, vol. 41, # 20, p. 2985 - 2992
[3] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1320 - 1322
[4] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57-58
[5] Tetrahedron, 1969, vol. 25, p. 3251 - 3266 |
| | 3-Nitrosalicylaldehyde Preparation Products And Raw materials |
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