PD 123319 二(三氟乙酸盐)
| 中文名称 | PD 123319 二(三氟乙酸盐) |
|---|---|
| 中文同义词 | PD 123319 二(三氟乙酸盐);(S)-1-(4-(二甲氨基)-3-甲基苄基)-5-(2,2-二苯基乙酰基)-4,5,6,7-四氢-1H-咪唑并[4,5-C]吡啶-6-甲酸 2,2,2-三氟乙酸 (1:2);PD123319 DI(TRIFLUOROACETATE),ANGIOTENSIN AT2 RECEPTOR拮抗剂;PD 123320;化合物 PD 123319 ditrifluoroacetate |
| 英文名称 | S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt |
| 英文同义词 | (S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate);PD 123319 bis(trifluoroacetate);PD 123,319 hydrate di(trifluoroacetate) salt;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt;PD123319; PD-123319; S-+-PD 123319;PD 123,319 di(trifluoroacetate) salt hydrate;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate;PD 123319 (trifluoroacetate salt) |
| CAS号 | 136676-91-0 |
| 分子式 | C33H33F3N4O5 |
| 分子量 | 622.65 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 136676-91-0.mol |
| 结构式 |  |
PD 123319 二(三氟乙酸盐) 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 在水中的溶解度为10mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至黄色 |
| 水溶解性 | Soluble to 100 mM in water |
| InChIKey | PTSUEYBWHKDYBS-FPCIESGBSA-N |
| SMILES | O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C |
PD 123319 ditrifluoroacetate 是一种有效的，选择性的 AT2 angiotensin II receptor 拮抗剂，IC50 值为 34 nM。
IC50: 34 nM (AT2 Receptor)
PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. 125 I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC 50 of 92.9 nM) for DuP-753. PD-123319 does not have any effect on 125 I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC 50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC 50 around 10 microM).
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-10259A | PD 123319 二(三氟乙酸盐) PD 123319 ditrifluoroacetate | 136676-91-0 | 1 mg | 405元 |
| 2026/06/05 | HY-10259A | PD 123319 二(三氟乙酸盐) PD 123319 ditrifluoroacetate | 136676-91-0 | 5 mg | 893元 |