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| | DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS Basic information |
| Product Name: | DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS | | Synonyms: | ADAM-17 SUBSTRATE II, FLUOROGENIC;ADAM-17 SUBSTRATE III, FLUOROGENIC;DABCYL-TNF-alpha-EDANS (-4 to +6) (human) trifluoroacetate salt;DABCYL-TNF-ALPHA-EDANS (-4 TO +6) (HUMAN);DABCYL-TUMOR NECROSIS FACTOR-ALPHA-EDANS (-4 TO +6) (HUMAN);DABCYL-LAQAVRSSSR-EDANS;DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS;TNF-ALPHA CONVERTASE ENZYME SUBSTRATE, FLUOROGENIC | | CAS: | 396716-14-6 | | MF: | C70H104N22O18S | | MW: | 1573.78 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 396716-14-6.mol |  |
| | DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS Chemical Properties |
| density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | 50% acetic acid: 5mg/mL
DMSO: 5mg/mL | | form | lyophilized solid | | pka | -0.26±0.40(Predicted) | | color | red | | Sequence | {DABCYL}-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-{EDANS} |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS Usage And Synthesis |
| Uses | DABCYL-TNF-α-EDANS (-4 to +6) (human) is a FRET peptide substrate of tumor necrosis factor convertase (TACE)[1]. | | Biological Activity | Cell permeable: no', 'Km = 19 μM as a fluorescence resonance energy transfer (FRET) peptide substrate for TACE', 'Primary Target
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE', 'Product does not compete with ATP.', 'Reversible: no | | References | [1] Liepinsh E, et al. NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding. J Biol Chem. 2003 Jul 11;278(28):25982-9. DOI:10.1074/jbc.M302734200 |
| | DABCYL-LEU-ALA-GLN-ALA-VAL-ARG-SER-SER-SER-ARG-EDANS Preparation Products And Raw materials |
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