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| | 5-Amino-3-chloropyridazine Basic information |
| Product Name: | 5-Amino-3-chloropyridazine | | Synonyms: | 4-PyridazinaMine, 6-chloro-;6-Chloro-4-pyridazinamine;3-Chloro-pyridazin-5-ylaMine;5-Amino-3-chloropyridazine 93%;5-AMINO-3-CHLOROPYRIDAZINE ISO 9001：2015 REACH;SWF-103;SW-103;6-Chloropyridazin-4-amine | | CAS: | 29049-45-4 | | MF: | C4H4ClN3 | | MW: | 129.55 | | EINECS: | | | Product Categories: | | | Mol File: | 29049-45-4.mol |  |
| | 5-Amino-3-chloropyridazine Chemical Properties |
| Melting point | 153-154 ºC | | Boiling point | 368.3±22.0 °C(Predicted) | | density | 1.437 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 4.55±0.10(Predicted) | | form | solid | | color | Light yellow to light brown |
| | 5-Amino-3-chloropyridazine Usage And Synthesis |
| Uses | 6-Chloro-4-pyridazinamine (cas# 29049-45-4) is a compound useful in organic synthesis. | | Application | 5-Amino-3-chloropyrazine, as an important structural unit of heterocyclic structures, possesses diverse chemical reactivity due to its pyrazine ring skeleton, chlorine atom, and amino functional group, making it a key intermediate for the synthesis of bioactive drug molecules and agrochemicals. | | Synthesis | General procedure for the synthesis of 6-chloro-4-amino pyridazine from 3,5-dichloropyridazine: 3,5-dichloropyridazine (1 g, 6.71 mmol, 1.0 eq.), ammonia (8 mL), and dioxane (2 mL) were added to a 25 mL round-bottom flask. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the resulting solid was collected by filtration. A final 570 mg (62% yield) of 6-chloro-4-aminopyridazine was obtained as a brown solid. The product was analyzed by LC-MS to confirm: (ES, m/z): retention time (RT) = 0.434 min, LCMS purity 53%, m/z = 130 [M + 1]. | | References | [1] Patent: WO2017/181177, 2017, A1. Location in patent: Paragraph 0941-0944 |
| | 5-Amino-3-chloropyridazine Preparation Products And Raw materials |
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