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| | 2,4-DICHLORO-6-METHYLQUINAZOLINE Basic information |
| Product Name: | 2,4-DICHLORO-6-METHYLQUINAZOLINE | | Synonyms: | 2,4-DICHLORO-6-METHYLQUINAZOLINE;6-Methyl-2,4-dichloroquinazoline;EOS-60385;2,4-Dichloro-6-methylquinazoline 97%;Quinazoline, 2,4-dichloro-6-methyl-;2,4-Dichloro-6-methylquinazoline,97% | | CAS: | 39576-82-4 | | MF: | C9H6Cl2N2 | | MW: | 213.06 | | EINECS: | | | Product Categories: | | | Mol File: | 39576-82-4.mol |  |
| | 2,4-DICHLORO-6-METHYLQUINAZOLINE Chemical Properties |
| Boiling point | 292.4±33.0 °C(Predicted) | | density | 1.418±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.30±0.30(Predicted) | | form | Solid | | Appearance | White to off-white Solid |
| | 2,4-DICHLORO-6-METHYLQUINAZOLINE Usage And Synthesis |
| Synthesis | 6-Methylquinazoline-2,4(1H,3H)-dione (550 mg, 3.12 mmol) was used as a starting material, which was dissolved in POCl3 (4.0 mL), followed by the addition of N,N'-diethylaniline (0.5 mL). The reaction mixture was heated to 135 °C and the reaction was stirred at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The precipitated solid was collected by filtration and dried to afford 2,4-dichloro-6-methylquinazoline (590 mg, 89% yield), which could be used in subsequent steps without further purification. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 461 - 467
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132
[3] Patent: WO2004/87680, 2004, A1. Location in patent: Page 162
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 308 - 312
[5] Patent: WO2008/16666, 2008, A2. Location in patent: Page/Page column 49 |
| | 2,4-DICHLORO-6-METHYLQUINAZOLINE Preparation Products And Raw materials |
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