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| | 2-AMINO-3-METHOXYPYRAZINE Basic information |
| | 2-AMINO-3-METHOXYPYRAZINE Chemical Properties |
| Melting point | 84-85℃ | | Boiling point | 241℃ | | density | 1.224 | | Fp | 100℃ | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 3.49±0.10(Predicted) | | Appearance | Off-white to light yellow Solid |
| HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 2-AMINO-3-METHOXYPYRAZINE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-amino-3-methoxypyrazine from 2-amino-3-chloropyrazine is as follows:
Pre-step A: Synthesis of 3-methoxy-2-pyrazinamine
3-Chloro-2-pyrazinamine (200 mg, 1.544 mmol) and sodium methanol (250 mg, 4.63 mmol) were dissolved in methanol (3.9 mL) and the mixture was placed in a microwave reactor, heated to 130°C, and reacted for 60 min. Upon completion of the reaction, the crude product was purified by reversed-phase high performance liquid chromatography (RP-HPLC) to afford 3-methoxy-2-pyrazinamine (113 mg, 0.903 mmol, 59% yield). Mass spectrum (electrospray positive ion mode) m/z: 125.8 ([MH]+). | | References | [1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column |
| | 2-AMINO-3-METHOXYPYRAZINE Preparation Products And Raw materials |
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