|
|
| | 6,8-dichloro-2,7-naphthyridin-1-ol Basic information |
| Product Name: | 6,8-dichloro-2,7-naphthyridin-1-ol | | Synonyms: | 6,8-dichloro-2,7-naphthyridin-1-ol;6,8-Dichloro-1-hydroxy-2,7-naphthyridine;6,8-Dichloro-2,7-naphthyridine-1(2H)-one;6,8-Dichloro-2,7-naphthyridin-1(2H);6,8-dichloro-2H-2,7-naphthyridin-1-one;2,7-Naphthyridin-1(2H)-one, 6,8-dichloro-;6,8-Dichloro-2,7-naphthyridin-1(2H)-one | | CAS: | 950746-21-1 | | MF: | C8H4Cl2N2O | | MW: | 215.04 | | EINECS: | | | Product Categories: | Non-Chiral heterocyclic compounds | | Mol File: | 950746-21-1.mol |  |
| | 6,8-dichloro-2,7-naphthyridin-1-ol Chemical Properties |
| density | 1.544 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | 6,8-dichloro-2,7-naphthyridin-1-ol Usage And Synthesis |
| Synthesis | Step 4: To a sealed reaction tube was added 2,6-dichloro-4-[(1E)-2-(dimethylamino)vinyl]pyridine-3-carbonitrile (4.0 g, 16.6 mmol) and concentrated hydrochloric acid (20 mL). The reaction mixture was stirred at 45 °C for 18 hours. After completion of the reaction, it was cooled to room temperature and ice water was added to the reaction solution to form a yellow slurry. The precipitate was collected by filtration, washed sequentially with cold water, ether and ethyl acetate, and then dried under vacuum to afford 6,8-dichloro-2,7-naphthyridin-1(2H)-one as a pale yellow solid (80% yield). Mass spectrum (MS) m/z: 215.0 (M + 1). 1H NMR (300 MHz, DMSO-d6): δ 11.75 (s, 1H), 7.76 (s, 1H), 7.50 (t, J = 6.6 Hz, 1H), 6.52 (d, J = 6.6 Hz, 1H). | | References | [1] Patent: WO2013/185353, 2013, A1. Location in patent: Page/Page column 21
[2] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0178; 0179
[3] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0179; 0180
[4] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0085; 0086
[5] Patent: CN104530042, 2017, B. Location in patent: Paragraph 0171; 0183; 0184; 0185 |
| | 6,8-dichloro-2,7-naphthyridin-1-ol Preparation Products And Raw materials |
|