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| | Nsc247561 Basic information |
| Product Name: | Nsc247561 | | Synonyms: | 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride;9-((3-(Dimethylamino)propyl)amino)-1-(hydroxy(oxido)amino)acridine;Aids128235;Aids-128235;Ledacrine;Nitracrine dihydrochloride;Nsc247561;1,3-Propanediamine, N1,N1-dimethyl-N3-(1-nitro-9-acridinyl)-, hydrochloride (1:2) | | CAS: | 6514-85-8 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Nsc247561 Structure]() |
| | Nsc247561 Chemical Properties |
| Melting point | 134-135 °C | | density | 1.37 g/cm3 |
| | Nsc247561 Usage And Synthesis |
| Uses | Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions and is approximately 100,000 times more potent than misonidazole. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect[1]. | | References | [1] Selective toxicity of nitracrine to hypoxic mammalian cells DOI:10.1038/bjc.1984.34
[2] Wilson WR, et al. Selective toxicity of nitracrine to hypoxic mammalian cells. Br J Cancer. 1984 Feb;49(2):215-23. DOI:10.1038/bjc.1984.34
[3] Gniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81. DOI:10.1016/0306-3623(94)00143-b
[4] Daghastanli NA, et al. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75(1-2):27-32. DOI:10.1016/j.jphotobiol.2004.04.005 |
| | Nsc247561 Preparation Products And Raw materials |
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