4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile

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4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile manufacturers

  • PF-998425
  • PF-998425 pictures
  • 2023-08-31
  • CAS:1076225-27-8
  • Min. Order: 1kg
  • Purity: 99.9%
  • Supply Ability: 20tons
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Basic information
Product Name:4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile
Synonyms:4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile;PF 998425;rel-(-)-4-[(1R,2R)-2-Hydroxycyclohexyl]-2-(trifluoroMethyl)benzonitrile;PF-0998425;Benzonitrile, 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-
CAS:1076225-27-8
MF:C14H14F3NO
MW:269.26
EINECS:
Product Categories:
Mol File:1076225-27-8.mol
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Structure
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Chemical Properties
Melting point 89-91 °C
Boiling point 365.2±42.0 °C(Predicted)
density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL
form powder
pka14.84±0.40(Predicted)
color white to off-white
InChI1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1
InChIKeyMENRRRXHFQYXDW-DGCLKSJQSA-N
SMILESO[C@@H]1CCCC[C@@H]1c2ccc(C#N)c(c2)C(F)(F)F
Safety Information
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Irrit. 2
MSDS Information
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Usage And Synthesis
UsesPF-998425 is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia.
Biological ActivityPF-998425 is a novel, nonsteroidal androgen receptor antagonist.
in vivo

PF-998425 (Compound (-)-6a) is rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (μL/min)/mg protein). In vivo clearance data in dogs are consistent with the high clearance predicted in vitro in rat. Following intravenous administration of PF-998425, mean systemic plasma clearance is 40 (mL/min)/kg. The mean apparent of volume of distribution at steady state is 6.5 L/kg, and the mean terminal phase half-life is 2.6 h[1].

4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile Preparation Products And Raw materials
Tag:4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile(1076225-27-8) Related Product Information
4-[Cyclopropyl(hydroxy)methyl]-3-methyl-2-(trifluoromethyl)benzonitrile CID 138111144 4-(Cyclopropyl(hydroxy)methyl)-2-(trifluoromethyl)benzonitrile 4-(Cyclobutyl(hydroxy)methyl)-2-(trifluoromethyl)benzonitrile 4-[Cyclobutyl(hydroxy)methyl]-3-methyl-2-(trifluoromethyl)benzonitrile Benzonitrile, 4-(2-hydroxycyclohexyl)-2-(trifluoromethyl)-