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BioBioPha Co., Ltd.
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| Tel: |
0871-65217109 13211707573; |
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| Products Intro: |
Product Name:Aristolactam BIII
CAS:53948-10-0
Package:5mg Remarks:BBP01057
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| Company Name: |
Wuhan ChemFaces Biochemical Co., Ltd.
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| Tel: |
18607101326 15172504745 |
| Email: |
aileen@chemfaces.com |
| Products Intro: |
Product Name:Aristolactam BIII
CAS:53948-10-0
Purity:>=98% Package:5mg ,10mg ,20mg ,50mg ,100mg; 200mg; 500mg,可根据客户需求定制
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:Aristolactam BIII
CAS:53948-10-0
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | Aristolactam BIII Basic information |
| Product Name: | Aristolactam BIII | | Synonyms: | Aristolactam BIII;Dibenz[cd,f]indol-4(5H)-one,1,2,9-trimethoxy-;1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one;1,2,9-Trimethoxydibenz[cd,f]indol-4(5H)-one | | CAS: | 53948-10-0 | | MF: | C18H15NO4 | | MW: | 309.32 | | EINECS: | | | Product Categories: | | | Mol File: | 53948-10-0.mol |  |
| | Aristolactam BIII Chemical Properties |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | color | Yellow |
| | Aristolactam BIII Usage And Synthesis |
| Description | Aristolactam BIII has moderate antitumor activity in selected cell lines.
Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro. | | Uses | Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1]. | | target | PAFR | | References | [1] Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695. DOI:10.1016/j.phymed.2021.153695 |
| | Aristolactam BIII Preparation Products And Raw materials |
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