7-Quinazolinecarboxylic acid, 2-chloro-, methyl ester manufacturers
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| | 7-Quinazolinecarboxylic acid, 2-chloro-, methyl ester Basic information |
| Product Name: | 7-Quinazolinecarboxylic acid, 2-chloro-, methyl ester | | Synonyms: | Methyl 2-chloroquinazoline-7-carboxylate;7-Quinazolinecarboxylic acid, 2-chloro-, Methyl ester;Methyl 2-chloro-quinazolin-7-carboxylate;2-Chloro-7-quinazolinecarboxylic acid methyl ester;methyl 2-chloroquinazolin...;Methyl 2-chloro-7-quinazolinecarboxylate | | CAS: | 953039-79-7 | | MF: | C10H7ClN2O2 | | MW: | 222.63 | | EINECS: | | | Product Categories: | | | Mol File: | 953039-79-7.mol |  |
| | 7-Quinazolinecarboxylic acid, 2-chloro-, methyl ester Chemical Properties |
| Boiling point | 328.6±24.0 °C(Predicted) | | density | 1.392±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. -20°C | | pka | -0.73±0.30(Predicted) | | Appearance | Light yellow to light green Solid |
| | 7-Quinazolinecarboxylic acid, 2-chloro-, methyl ester Usage And Synthesis |
| Synthesis | Step 3. Preparation of methyl 2-chloroquinazoline-7-carboxylate
To methyl 2-oxo-1,2-dihydroquinazoline-7-carboxylate (1.0 eq.) was added phosphorous trichloride (POCl3, 3.0 eq.), the reaction mixture was heated to 100 °C and the reaction was stirred at this temperature for 20 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by slowly pouring into ice water. The precipitated solid product was collected by filtration and washed with cold water. The resulting solid was dried overnight under high vacuum to afford methyl 2-chloroquinazoline-7-carboxylate in 60% yield. The product was confirmed by electrospray mass spectrometry (ES/MS), m/z 223 (MH+). | | References | [1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 341 |
| | 7-Quinazolinecarboxylic acid, 2-chloro-, methyl ester Preparation Products And Raw materials |
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