ceftaroline fosamil acetate monohydrate manufacturers
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| | ceftaroline fosamil acetate monohydrate Basic information |
| Product Name: | ceftaroline fosamil acetate monohydrate | | Synonyms: | 4-[2-[[(6R,7R)-2-Carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydrate;TAK 599 acetate H2O;4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-(ethoxyimino)[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methylpyridinium acetate hydra;ceftaroline fosamil acetate monohydrate;Ceftaroline fosamil (hydrate)(acetate);Pyridinium, 4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-, acetate, hydrate (1:1:1);Ceftaroline fosamil acetate hydrate - Bio-X ? | | CAS: | 400827-55-6 | | MF: | C22H22N8O8PS4.C2H3O2.H2O | | MW: | 762.76 | | EINECS: | | | Product Categories: | | | Mol File: | 400827-55-6.mol |  |
| | ceftaroline fosamil acetate monohydrate Chemical Properties |
| | ceftaroline fosamil acetate monohydrate Usage And Synthesis |
| Uses | Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP)[1][2][3]. | | in vivo | Ceftaroline fosamil hydrate(s.c.) shows protective effects against experimental systemic infection caused by S. aureus N133 in mice, with ED50s of 1.60-2.37 mg/kg[1].
Ceftaroline fosamil hydrate (10 mg/kg; s.c.) disappeares rapidly and converts smoothly into T-91825 in blood of rats and monkeys[1]. | | IC 50 | β-lactam | | References | [1] Ishikawa T, et, al. TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties. Bioorg Med Chem. 2003 May 29;11(11):2427-37. DOI:10.1016/s0968-0896(03)00126-3
[2] Biek D, et al. Ceftaroline fosamil: a novel broad-spectrum cephalosporin with expanded anti-Gram-positive activity. J Antimicrob Chemother. 2010 Nov;65 Suppl 4:iv9-16. DOI:10.1093/jac/dkq251
[3] Parish D, et al. Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection. Curr Opin Investig Drugs. 2008 Feb;9(2):201-9. PMID:18246523 |
| | ceftaroline fosamil acetate monohydrate Preparation Products And Raw materials |
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