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| | 4-Amino-3,5-difluorobenzoic acid Basic information |
| | 4-Amino-3,5-difluorobenzoic acid Chemical Properties |
| Boiling point | 294.2±40.0 °C(Predicted) | | density | 1.536±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 4.18±0.10(Predicted) | | form | powder | | color | Faint to light orange |
| | 4-Amino-3,5-difluorobenzoic acid Usage And Synthesis |
| Uses | 4-Amino-3,5-difluorobenzoic Acid can be used to treat gastric cancer. | | Synthesis | The general procedure for the synthesis of 3,5-difluoro-4-aminobenzoic acid from 4-amino-3,5-difluorobenzonitrile was as follows: 4-amino-3,5-difluorobenzonitrile (354.3 mg, 2.3 mmol) was suspended in a 1 M aqueous sodium hydroxide solution (12 mL), and the resulting suspension was heated and reacted for 16 hours at 110 °C. After completion of the reaction, the mixture was cooled to room temperature and washed with ether. Subsequently, the aqueous phase was acidified to pH=2 with 10% KHSO4/Na2SO4 buffer and extracted with ethyl acetate (2×). The ethyl acetate extracts were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 3,5-difluoro-4-aminobenzoic acid (335 mg, 84% yield) as a yellow solid.1H NMR (300 MHz, chloroform-d) δ 7.66-7.58 (m, 2H). | | References | [1] Journal of Materials Chemistry C, 2016, vol. 4, # 23, p. 5326 - 5333
[2] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 3, p. 250 - 255
[3] Patent: WO2018/136935, 2018, A1. Location in patent: Paragraph 00408
[4] Bioconjugate Chemistry, 2018, vol. 29, # 2, p. 324 - 334
[5] Journal of the American Chemical Society, 2012, vol. 134, # 51, p. 20597 - 20600 |
| | 4-Amino-3,5-difluorobenzoic acid Preparation Products And Raw materials |
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