618094-85-2 manufacturers
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| | 618094-85-2 Basic information |
| Product Name: | 618094-85-2 | | Synonyms: | Guan-fu base A hydrochloride;Guanfu base A hydrochloride(1394485 free base),Guan fu base A hydrochloride(1394 48 5 free base) | | CAS: | 618094-85-2 | | MF: | ClH | | MW: | 36.46094 | | EINECS: | | | Product Categories: | | | Mol File: | 618094-85-2.mol |  |
| | 618094-85-2 Chemical Properties |
| InChI | InChI=1S/ClH/h1H | | InChIKey | VEXZGXHMUGYJMC-UHFFFAOYSA-N | | SMILES | [H]Cl |
| | 618094-85-2 Usage And Synthesis |
| Uses | Guanfu base A hydrochloride is an antiarrhythmic alkaloid with the ability to inhibit CYP2D6 enzyme activity. Guanfu base A hydrochloride can be used to inhibit arrhythmia-related diseases. Guanfu base A hydrochloride exhibits inhibitory effects on CYP2D6 in different species of organisms, including humans, monkeys, and dogs. The biological activity of Guanfu base A hydrochloride makes it have potential clinical application value[1]. | | References | [1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms DOI:10.1124/dmd.114.060905
[3] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380 |
| | 618094-85-2 Preparation Products And Raw materials |
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