(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID
| 中文名称 | (AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID |
|---|---|
| 中文同义词 | 化合物 T23489;化合物 UBP301;UBP 301,红藻氨酸拮抗剂 |
| 英文名称 | (αS)-alpha-amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid |
| 英文同义词 | (alphaS)-alpha-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid;(αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoicacid;UBP 301;(aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoicacid;UBP-301,UBP301;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-, (αS)-;(αS)-alpha-amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid |
| CAS号 | 569371-10-4 |
| 分子式 | C15H14IN3O6 |
| 分子量 | 459.19 |
| EINECS号 | |
| 相关类别 | Amino Acids & Derivatives;Aromatics;Glutamate receptor;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 569371-10-4.mol |
| 结构式 | ![(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID 结构式](CAS/GIF/569371-10-4.gif) |
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID 性质
| 熔点 | 214.1-214.4 °C(Solv: water (7732-18-5)) |
|---|---|
| 沸点 | 636.1±65.0 °C(Predicted) |
| 密度 | 1.98±0.1 g/cm3(Predicted) |
| 储存条件 | Store at +4°C |
| 溶解度 | DMSO：0.5 mg/ml（温和加热） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 2.12±0.10(Predicted) |
(AS)-ALPHA-AMINO-3-[(4-CARBOXYPHENYL)METHYL]-3,4-DIHYDRO-5-IODO-2,4-DIOXO-1(2H)-PYRIMIDINEPROPANOIC ACID 用途与合成方法
UBP301 是一种有效的选择性红藻氨酸受体 (kainate receptor) 拮抗剂，其 IC50 和 KD 值分别为 164 μM 和 5.94 μM。UBP301 对红藻氯酸受体的选择性比 AMPA 受体高 30 倍。UBP301 是 Willardiine 的衍生物。