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| | Methyl 3-(broMoMethyl)-2-nitrobenzoate Basic information |
| Product Name: | Methyl 3-(broMoMethyl)-2-nitrobenzoate | | Synonyms: | Methyl 3-(broMoMethyl)-2-nitrobenzoate;3-Bromomethyl-2-nitro-benzoic acid methyl ester;Benzoic acid, 3-(bromomethyl)-2-nitro-, methyl ester;2-Nitro-3-bromomethylbenzoic acid methyl ester | | CAS: | 132874-06-7 | | MF: | C9H8BrNO4 | | MW: | 274.07 | | EINECS: | | | Product Categories: | | | Mol File: | 132874-06-7.mol |  |
| | Methyl 3-(broMoMethyl)-2-nitrobenzoate Chemical Properties |
| Boiling point | 349.8±32.0 °C(Predicted) | | density | 1.624±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | Appearance | White to off-white Solid |
| | Methyl 3-(broMoMethyl)-2-nitrobenzoate Usage And Synthesis |
| Synthesis | Step B: Synthesis of methyl 3-(bromomethyl)-2-nitrobenzoate; A mixture of methyl 3-methyl-2-nitrobenzoate (12.34 g, 63.23 mmol), benzoyl peroxide (0.920 g, 3.80 mmol) and N-bromosuccinimide (11.25 g, 63.21 mmol) in carbon tetrachloride (330 mL) was heated at refluxed for 12 h. The reaction was carried out under nitrogen protection. Upon completion of the reaction, the cooled mixture was diluted with dichloromethane (150 mL), treated with silica gel (30 g) and the solvent was removed under reduced pressure. The residue was purified by fast column chromatography on silica gel using ethyl acetate/hexane (15:85) as eluent to afford methyl 3-(bromomethyl)-2-nitrobenzoate (1B) as a light yellow solid (7.15 g, 41% yield). The product was confirmed by 1H NMR (CDCl3): δ 3.91 (s, 3H), 4.46 (s, 2H), 7.58 (t, 1H), 7.74 (dd, 1H), 7.96 (dd, 1H). | | References | [1] Organic and Biomolecular Chemistry, 2014, vol. 12, # 30, p. 5629 - 5633
[2] Organic Process Research and Development, 2011, vol. 15, # 4, p. 831 - 840
[3] Journal of Organic Chemistry, 1997, vol. 62, # 17, p. 5838 - 5845
[4] Tetrahedron, 2004, vol. 60, # 10, p. 2235 - 2246
[5] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 88 |
| | Methyl 3-(broMoMethyl)-2-nitrobenzoate Preparation Products And Raw materials |
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