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| | 2,4,6-Trimethoxybenzaldehyde Basic information |
| Product Name: | 2,4,6-Trimethoxybenzaldehyde | | Synonyms: | TIMTEC-BB SBB000351;Benzaldehyde, 2,4,6-trimethoxy-;PHLOROGLUCINOL ALDEHYDE TRIMETHYL ETHER;PHLOROGLUCINALDEHYDE TRIMETHYL ETHER;AKOS BBS-00003255;2,4,6-TRIMETHOXYBENZALDEHYDE;2,4,6-Trimethoxybenzaldehyde98%;1-Formyl-2,4,6-trimethoxybenzene | | CAS: | 830-79-5 | | MF: | C10H12O4 | | MW: | 196.2 | | EINECS: | 212-598-2 | | Product Categories: | C10 to C21;Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted);BUILDING BLOCKS;FINE Chemical & INTERMEDIATES;Aldehydes;blocks;bc0001 | | Mol File: | 830-79-5.mol |  |
| | 2,4,6-Trimethoxybenzaldehyde Chemical Properties |
| Melting point | 115-120 °C (lit.) | | Boiling point | 293.08°C (rough estimate) | | density | 1.2166 (rough estimate) | | refractive index | 1.5550 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Crystalline Powder | | color | Beige | | Water Solubility | Insoluble in water. | | Sensitive | Air Sensitive | | BRN | 1956051 | | InChI | InChI=1S/C10H12O4/c1-12-7-4-9(13-2)8(6-11)10(5-7)14-3/h4-6H,1-3H3 | | InChIKey | CRBZVDLXAIFERF-UHFFFAOYSA-N | | SMILES | C(=O)C1=C(OC)C=C(OC)C=C1OC | | CAS DataBase Reference | 830-79-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4,6-Trimethoxybenzaldehyde(830-79-5) |
| | 2,4,6-Trimethoxybenzaldehyde Usage And Synthesis |
| Chemical Properties | pink crystal power | | Uses | 2,4,6-Trimethoxybenzaldehyde was used in the preparation and characterization of three RNA-specific fluorescent probes and their use in live cell imaging. It was used as starting reagent for the regioselective synthesis of new (+/-)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins. | | General Description | 2,4,6-Trimethoxybenzaldehyde exhibits significant anti-candida activity. | | Synthesis | The reaction system was cooled to -5 to 0 °C under nitrogen protection using 1,3,5-trimethoxybenzene (40 g, 0.22 mol) and N,N-dimethylformamide. Subsequently, phosphoryl chloride (48 g, 0.5 mol) was slowly added dropwise over 30 to 45 minutes. After the dropwise addition was completed, the reaction mixture was kept at 0 °C and stirring was continued for 1 hour. Upon completion of the reaction, the mixture was poured onto crushed ice and neutralized with saturated sodium carbonate solution. The precipitate precipitated was collected by filtration and washed with distilled water to give the final 2,4,6-trimethoxybenzaldehyde. Yield: 46 g (98% yield); 1H NMR (CDCl3): δ 10.35 (s, 1H), 6.67 (s, 2H), 3.88 (s, 6H), 3.87 (s, 3H); Mass Spectrum (MS): m/e 197 (M + 1). | | References | [1] Journal of Chemical Research, Miniprint, 1991, # 9, p. 2401 - 2413
[2] Patent: WO2011/121505, 2011, A1. Location in patent: Page/Page column 42
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 28, p. 6359 - 6369
[4] Patent: US2017/182051, 2017, A1. Location in patent: Paragraph 0122
[5] Journal of Chemical Research, 2015, vol. 39, # 8, p. 458 - 461 |
| | 2,4,6-Trimethoxybenzaldehyde Preparation Products And Raw materials |
| Raw materials | Bromine-->Dimethyl sulfate-->Sodium Methoxide-->Copper(I) chloride-->1,2-Dichlorobenzene-->Formamide, N-(chloromethyl)-N-formyl--->1,3,5-Trimethoxy-4-iodobenzene-->2,4,6-TRIMETHOXYBENZYL ALCOHOL-->[(difluoromethyl)thio]benzene-->2',4',6'-TRIMETHOXYACETOPHENONE-->1,3,5-Trimethoxybenzene | | Preparation Products | Pentaerythritol-->Bianthrone-->dracorhodin-->IC 261-->1-(2,4,6-TRIMETHOXY-PHENYL)-PROP-2-YN-1-OL |
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