OSI-754

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:CP-609754 (OSI754)
CAS:1190094-64-4
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:CP-609754
CAS:1190094-64-4
Package:100 mg Remarks:Reach out to us for more information about custom solutions.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:CP-609754
CAS:1190094-64-4
Purity:99.04% Package:1mg;50USD|5mg;118USD|10mg;197USD
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:CP-609754 (OSI754, LNK 754)
CAS:1190094-64-4
Purity:98% Package:10mg Remarks:V3986
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:CP-609754
CAS:1190094-64-4
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

OSI-754 manufacturers

  • CP-609754
  • CP-609754 pictures
  • $50.00 / 1mg
  • 2026-05-11
  • CAS:1190094-64-4
  • Min. Order:
  • Purity: 99.87%
  • Supply Ability: 10g
  • CP-609754
  • CP-609754 pictures
  • $1.00 / 1G
  • 2018-07-23
  • CAS:1190094-64-4
  • Min. Order: 1MG
  • Purity: >98%
  • Supply Ability: 100G
OSI-754 Basic information
Product Name:OSI-754
Synonyms:OSI-754;CP 609754;LNK 754;CP-609754 (OSI754);6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one;2(1H)-Quinolinone, 6-[(R)-(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-ethynylphenyl)-1-methyl-;CP-609754(OS1754);CP-609754 (OSI754, LNK 754)
CAS:1190094-64-4
MF:C29H22ClN3O2
MW:479.96
EINECS:
Product Categories:
Mol File:1190094-64-4.mol
OSI-754 Structure
OSI-754 Chemical Properties
Boiling point 702.4±60.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (208.35 mM; Need ultrasonic)
pka12.28±0.29(Predicted)
form Solid
color Off-white to yellow
InChIInChI=1/C29H22ClN3O2/c1-4-19-6-5-7-20(14-19)24-16-28(34)33(3)26-13-10-22(15-25(24)26)29(35,27-17-31-18-32(27)2)21-8-11-23(30)12-9-21/h1,5-18,35H,2-3H3/t29-/s3
InChIKeyJAHDAIPFBPPQHQ-NNFJEGBSNA-N
SMILESN1(C)C2=C(C=C([C@@](C3=CC=C(Cl)C=C3)(O)C3N(C)C=NC=3)C=C2)C(C2=CC=CC(C#C)=C2)=CC1=O |&1:6,r|
Safety Information
MSDS Information
OSI-754 Usage And Synthesis
UsesCP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL[1]. CP-609754 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo

CP-609754 (CP-609,754) has antitumor activity against 3T3 H-ras (61L) tumors in vivo[1].
With twice daily oral dosing of CP-609754, tumor regression is achieved with a dose of 100 mg/kg; the ED50 for tumor growth inhibition is 28 mg/kg[1].
With continuous i.p. infusion of CP-609754, tumor growth is inhibited by >50%, and tumor farnesyltransferase activity inhibited by >30% in mice in which the plasma concentration of CP-609754 is maintained above 118 ng/mL[1].

References[1] Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35. DOI:10.1158/1078-0432.CCR-04-0901
OSI-754 Preparation Products And Raw materials
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