Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl)

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Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Email: customer_service@efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: Shanghai Amole Biotechnology Co., Ltd.  
Tel: 13370042665 18916960931
Email: 2596183085@qq.com
Company Name: Wuxi Lihengsheng Biopharmaceutical Technology Co., Ltd  
Tel: 15250805028 15250805028
Email: 649163353@qq.com

Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) manufacturers

  • PF-03049423
  • PF-03049423 pictures
  • $79.00
  • 2026-07-14
  • CAS:954138-07-9
  • Purity: 99.93%
  • Supply Ability: 10g
Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) Basic information
Product Name:Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl)
Synonyms:Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl);3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one;3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-1H,2H-pyrido[3,4-b]pyrazin-2-one;PF-03049423 free base
CAS:954138-07-9
MF:C24H32N6O4
MW:468.54868
EINECS:
Product Categories:
Mol File:954138-07-9.mol
Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) Structure
Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) Chemical Properties
Safety Information
MSDS Information
Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) Usage And Synthesis
UsesPF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke[1].
in vivo

PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion[1].
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].

Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model[1]
Dosage:0.1, 1, or 10 mg/kg
Administration:Subcutaneous injection, b.i.d. for 7 days
Result:Improved functional recovery at 1 mg/kg and 10 mg/kg.
IC 50PDE5A; rat and human platelet enzyme: ~0.2 nM (IC50)
References[1] Menniti FS, et al. Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. J Pharmacol Exp Ther. 2009 Dec;331(3):842-50. DOI:10.1124/jpet.109.156919
Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl) Preparation Products And Raw materials
Tag:Pyrido[3,4-b]pyrazin-2(1H)-one, 3-[4-(2-hydroxyethyl)-1-piperazinyl]-7-(6-Methoxy-3-pyridinyl)-1-(2-propoxyethyl)(954138-07-9) Related Product Information
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