(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one
CAS:879551-04-9
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: Shenzhen Nexconn Pharmatechs Ltd
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Products Intro: Product Name:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one
CAS:879551-04-9
Purity:98% Package:1KG;10KG;50KG
Company Name: career henan chemical co
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Products Intro: Product Name:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one
CAS:879551-04-9
Purity:99% Package:1KG;7USD
Company Name: Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
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Products Intro: Product Name:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-one
CAS:879551-04-9
Purity:0.97 Package:1KG;25KG
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
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Products Intro: Product Name:(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-dihydrofuran-2(3H)-one
CAS:879551-04-9
Purity:0.99 Package:1KG;5KG;100KG;1000KG Remarks:1KG,5KG,25KG,200KG

(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one manufacturers
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Basic information
Product Name:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one
Synonyms:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one;(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyloxolan-2-one;(3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHYL-DIHYD;(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone;(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-one;D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, |-lactone;D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, gamma-lactone;-3-Fluoro-4-hydroxy-5-(hydroxymethyl)
CAS:879551-04-9
MF:C6H9FO4
MW:164.13
EINECS:
Product Categories:Sofosbuvir intermediate
Mol File:879551-04-9.mol
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Structure
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Chemical Properties
Melting point 142-143℃ (ethyl acetate heptane )
Boiling point 352.7±42.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka11.46±0.60(Predicted)
AppearanceOff-white to light brown Solid
Safety Information
MSDS Information
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Usage And Synthesis
Uses(3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyldihydrofuran-2(3H)-one can be used for synthetic preparation for asymmetric synthesis of dibenzoyl fluoro methyl-D-ribono-γ-lactone via asymmetric aldol condensation and enzymic hydrolysis from isopropylidene-D-glyceraldehyde and Et fluoropropionate.
SynthesisChlorination or acylation of trans-5-hydroxy-1,3-oxathiolane-2-carboxylic acid-L menthol ester and coupling with cytosine and 5-fluorocytosine or with silicone-protected cytosine and 5-fluorocytosine. -The process of chlorination or acylation requires high requirements for the maintenance of the chiral structure, prolongs the process flow, increases the process cost, and reduces the yield of the final product.
(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one Preparation Products And Raw materials
Preparation Products(2R)-2-Deoxy-2-fluoro-2-Methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate)-->((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate
Tag:(3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyl-dihydrofuran-2(3H)-one(879551-04-9) Related Product Information
Sofosbuvir L-Alanine, N-[(R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester L-Alanine isopropyl ester hydrochloride (2'R)-2'-Deoxy-2'-fluoro-2'-Methyl-uridine 3',5'-dibenzoate 2'-deoxy-2'-fluoro-2'-C-methyluridine PSI-6130 derivative ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate 4-Pyridinecarboxamide, 3-chloro-N-methyl- 3-Pyridinecarboxamide, 4-chloro-N-methyl- ((2R,3S,4S)-3-(benzoyloxy)-4-fluoro-4-Methyl-5-oxotetrahydrofuran-2-yl)Methyl benzoate N4-Benzoylcytosine (2R)-2-Deoxy-2-fluoro-2-Methyl-D-erythro-pentonic acid-g-lactone 3,5-bis(4-chlorobenzoate) 2'-C-Methyl-, 2',3',5'-tribenzoateuridine 2'-deoxy-2'-fluoro-2'-C-methylcytidine 3-Pyridinecarboxamide, 5-chloro-N-methyl- 1-(5-Bromo-4-methylthiophen-2-yl)ethanone Pyrimidine nucleoside antibiotic