- 4-Cyanopiperidine
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- $0.00 / 1KG
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2025-04-04
- CAS:4395-98-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
- 4-Cyanopiperidine
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- $1.00 / 1kg
-
2019-07-06
- CAS:4395-98-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: as request
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| | 4-Cyanopiperidine Basic information |
| | 4-Cyanopiperidine Chemical Properties |
| Melting point | 0°C | | Boiling point | 0°C | | density | 0.987 g/mL at 25 °C | | refractive index | 1.4755 | | Fp | 0°C | | storage temp. | 2-8°C | | solubility | Soluble in chloroform. | | pka | 9.26±0.10(Predicted) | | form | Liquid | | color | Colorless to pale yellow | | InChI | InChI=1S/C6H10N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-4H2 | | InChIKey | FSDNTQSJGHSJBG-UHFFFAOYSA-N | | SMILES | N1CCC(C#N)CC1 | | CAS DataBase Reference | 4395-98-6(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 20/21/22-36/37/38-41-22 | | Safety Statements | 26-36/37/39-36-39 | | RIDADR | 3276 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29333990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1 |
| | 4-Cyanopiperidine Usage And Synthesis |
| Chemical Properties | Yellowish-Orangish Oil | | Uses | 4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances like antidepressants and anti-inflammatory. It is used as a precursor for the synthesis of piperidine derivatives. | | Synthesis | The general procedure for the synthesis of 4-cyanopiperidine from N-Boc-4-cyanopiperidine is as follows:
Step A: Preparation of 4-cyanopiperidine hydrochloride (mt17-1)
N-Boc-4-cyanopiperidine (4.00 g, 19.0 mmol) was dissolved in 20 mL of 4M HCl/EtOAc solution and stirred at room temperature for 30 min. After completion of the reaction, the mixture was concentrated under vacuum to give 2.10 g of 4-cyanopiperidine hydrochloride (mt17-1) as a white solid in 100% yield.
1H-NMR (DMSO-d6) δ: 9.32 (br, 1H), 3.18-3.08 (m, 3H), 2.97-2.92 (m, 2H), 2.08-2.04 (m, 2H), 1.95-1.85 (m, 2H). | | References | [1] Patent: WO2014/178, 2014, A1. Location in patent: Page/Page column 102
[2] Patent: WO2014/4416, 2014, A1. Location in patent: Page/Page column 102
[3] Patent: US2014/5103, 2014, A1. Location in patent: Paragraph 0459; 0460
[4] Patent: US2015/197531, 2015, A1. Location in patent: Paragraph 0460
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 7, p. 822 - 829 |
| | 4-Cyanopiperidine Preparation Products And Raw materials |
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