- IKK 16
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- $34.00 / 1mg
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2026-04-22
- CAS:873225-46-8
- Min. Order:
- Purity: 98.76%
- Supply Ability: 10g
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| | IKK 16 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O | | form | solid | | color | White to yellow | | InChIKey | BWZJBXAPRCVCKQ-UHFFFAOYSA-N | | SMILES | C(C1=CC=C(NC2=NC=CC(C3SC4=CC=CC=C4C=3)=N2)C=C1)(N1CCC(N2CCCC2)CC1)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | IKK 16 Usage And Synthesis |
| Uses | IKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders. | | Definition | ChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides. | | Biological Activity | ikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1]. | | in vivo | IKK 16 also demonstrates significant in vivo activity in an acute model of cytokine release. Both routes of administration of IKK 16 (30 mg/kg, sc) or orally (30 mg/kg, p.o) at the indicated dose results in a significant inhibition of 86% (sc) and 75% (p.o.). IKK 16(10 mg/kg, sc) is also active in the thioglycollate-induced peritonitis model in the mouse. The maximal inhibition of neutrophil extravasation in this model is about 50%[1]. Treatment of septic mice with IKK 16 (1 mg/kg body weight i.v.) results in a significantly increased degree of phosphorylation (P<0.05) of serine residues on Akt and eNOS in the liver[3]. | | target | IKK-2 | | IC 50 | IKK2: 40 nM (IC50); IKK1: 200 nM (IC50); IKK: 70 nM (IC50); LRRK2: 50 nM (IC50) | | references | [1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19. |
| | IKK 16 Preparation Products And Raw materials |
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