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Fluxapyroxad

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Products Intro: Product Name:fluxapyroxad
CAS:907204-31-3
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Products Intro: Product Name:Fluxapyroxad
CAS:907204-31-3
Purity:0.98 Package:1KG;5KG;25KG Remarks:White to off white powder
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CAS:907204-31-3
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Products Intro: Product Name:Fluxapyroxad
CAS:907204-31-3
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Fluxapyroxad Basic information
Product Name:Fluxapyroxad
Synonyms:Fluxapyroxad;3-(Difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxaMide, 3-(difluoroMethyl)-1-Methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)-;3-(Difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide;3-(DIFLUOROMETHYL)-1-METHYL-N-(3,4,5-TRIFLUORO-[1,1-BIPHENYL]-2-YL)-1H-PYRAZOLE-4-CARBOXAMIDE;Fluxapyroxad@1000 μg/mL in Acetonitrile;Fluxapyroxad@100 μg/mL in Acetonitrile;Fluxapyroxad Solution in Acetonitrile, 100μg/mL
CAS:907204-31-3
MF:C18H12F5N3O
MW:381.3
EINECS:
Product Categories:907204-31-3
Mol File:907204-31-3.mol
Fluxapyroxad Structure
Fluxapyroxad Chemical Properties
Boiling point 428.4±45.0 °C(Predicted)
density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 100 mg/mL (262.26 mM)
pka11.73±0.70(Predicted)
form Solid
color White to off-white
BRN 15702063
Henry's Law Constant3.3×106 mol/(m3Pa) at 25℃, Maniere et al. (2011)
Major Applicationagriculture
environmental
InChIInChI=1S/C18H12F5N3O/c1-26-8-11(16(25-26)17(22)23)18(27)24-14-5-3-2-4-10(14)9-6-12(19)15(21)13(20)7-9/h2-8,17H,1H3,(H,24,27)
InChIKeySXSGXWCSHSVPGB-UHFFFAOYSA-N
SMILESN1(C)C=C(C(NC2=CC=CC=C2C2=CC(F)=C(F)C(F)=C2)=O)C(C(F)F)=N1
EPA Substance Registry System1H-Pyrazole-4-carboxamide, 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)- (907204-31-3)
Safety Information
Hazard Codes Xn,N
Risk Statements 40-50/53
Safety Statements 36/37-60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAquatic Acute 1
Aquatic Chronic 1
Carc. 2
Lact.
MSDS Information
Fluxapyroxad Usage And Synthesis
Chemical PropertiesFlumioxazin is white crystal, melting point 156.8℃, relative density 1.42 (room temperature), vapor pressure (25℃) >8.1×10-9 Pa. Its solubility at room temperature (g/L, 20℃): acetone >250, acetonitrile 167.6±0.2, methylene chloride 146.1±0.3, ethyl acetate 123.3±0.2, methanol 53.4, toluene 20.0, n-octanol 4.69, n-heptane 0.106. Kow logP is 3.08 (deionized water, 3.09 (pH 4), n-heptanol 0.106. 20.0, n-octanol 4.69, n-heptane 0.106. octanol/water partition coefficients (20°C) Kow logP were 3.08 (deionized water), 3.09 (pH 4), 3.13 (pH 7), 3.09 (pH 9).
UsesFluxapyroxad is a new generation carboxamide funugicide and its residues are found in food. Pesticide component.
DefinitionChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those elonging to the Ascomycetes, Basidiomycetes and Zygomycetes families.
in vivo

Fluxapyroxad (10 mg/kg/day, po via diet for 13 weeks) induces the body weight gain reduction, colon length reduction, intestinal barrier integrity impairment and proinflammatory cytokines secretion, inducing chronic colonic inflammation in C57BL/6 J mice[2].

Animal Model:C57BL/6 J mouse model[2].
Dosage:10 mg/kg/day
Administration:po via diet for 13 weeks
Result:Decreased body weight gain, shortened the colon length, damaged the colonic crypts, increased the levels of proinflammatory cytokines IL-6, IL-1β, and TNF-α, decreased the level of IL-22, impaired the intestinal barrier integrity.
Tag:Fluxapyroxad(907204-31-3) Related Product Information
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