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| | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Basic information |
| Product Name: | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline | | Synonyms: | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline;Naquotinib intermediate;4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine;Benzenamine, 4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-;1,3-Propanediol,1-(7-piperidinyl)-;4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzenamine | | CAS: | 959795-70-1 | | MF: | C16H26N4 | | MW: | 274.4 | | EINECS: | | | Product Categories: | | | Mol File: | 959795-70-1.mol |  |
| | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Chemical Properties |
| Boiling point | 447.2±45.0 °C(Predicted) | | density | 1.114±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 8.14±0.42(Predicted) | | Appearance | Off-white to gray Solid |
| | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Usage And Synthesis |
| Uses | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline acts as a reagent in the preparation of Gilteritinib derivatives as inhibitors of FLT3-Axl. | | Synthesis | GENERAL METHOD: 1-methyl-4-(1-(4-nitrophenyl)piperidin-4-yl)piperazine (2.18 g, 6.52 mmol) was dissolved in ethanol (50 mL) and 10% palladium carbon (wet basis, 53% water; 600 mg) was added. The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 8 hours. Upon completion of the reaction, the insoluble material was removed by Celite filtration and the filtrate was concentrated under vacuum to afford 4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1.96 g, 99%) as a light purple solid. | | References | [1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 3, p. 251 - 262
[2] Patent: US2009/318441, 2009, A1. Location in patent: Page/Page column 45
[3] European Journal of Medicinal Chemistry, 2019, p. 690 - 709 |
| | 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Preparation Products And Raw materials |
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