| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- Nat-20(S)-yne
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- $218.00
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2026-05-11
- CAS:1397692-46-4
- Purity:
- Supply Ability: 10g
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| | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Basic information |
| Product Name: | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol | | Synonyms: | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol;SCMAJJQBADBBSM-CMJRPVKTSA-N;Nat-20(S)-yne;Nat-20(S)-yne Exclusive;26,27-Dinorcholest-5-en-24-yne-3,20-diol, (3β)-;Nat20(S)yne,Nat 20(S) yne;(3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol, CAS 1397692-46-4 | | CAS: | 1397692-46-4 | | MF: | C25H38O2 | | MW: | 370.57 | | EINECS: | | | Product Categories: | Pharmaceuticals, Intermediates & Fine Chemicals, Steroids | | Mol File: | 1397692-46-4.mol |  |
| | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Chemical Properties |
| Boiling point | 510.0±25.0 °C(Predicted) | | density | 1.08±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 14 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 14.68±0.29(Predicted) |
| | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Usage And Synthesis |
| Description | Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO. | | Uses | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol is a byproduct of cholesterol (C432501) oxidation and a potential agonists of the hedgehog signaling pathway. | | References | [1] YOONJUNG KHO. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 34: 12479-12484. DOI: 10.1073/pnas.0403413101
[2] JEAN-FRANOIS LUTZ Zoya Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide–alkyne “click” chemistry[J]. Advanced drug delivery reviews, 2008, 60 9: Pages 958-970. DOI: 10.1016/j.addr.2008.02.004
[3] SIGRID NACHTERGAELE. Oxysterols are allosteric activators of the oncoprotein Smoothened[J]. Nature chemical biology, 2012, 8 2: 211-220. DOI: 10.1038/nchembio.765 |
| | (3β)-26,27-Dinorcholest-5-en-24-yne-3,20-diol Preparation Products And Raw materials |
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