4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺
| 中文名称 | 4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺 |
|---|---|
| 中文同义词 | 4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺;化合物CDN1163;CDN 1163,SERCA2变构激活剂;化合物CDN1163,10 MM DMSO 溶液;CDN1163试剂;892711-75-0;CDN1163;CDN1163试剂 |
| 英文名称 | CDN 1163 |
| 英文同义词 | N-(2-methylquinolin-8-yl)-4-propan-2-yloxybenzamide;4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide;4-isopropoxy-N-(2-methylquinolin-8-yl)benzamide;CDN1163;Benzamide, 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-;Inhibitor,CDN 1163,Calcium Channel,Ca channels,Ca2+ channels,CDN-1163,CDN1163,inhibit;CDN1163, 10 mM in DMSO |
| CAS号 | 892711-75-0 |
| 分子式 | C20H20N2O2 |
| 分子量 | 320.39 |
| EINECS号 | |
| 相关类别 | 抑制剂 |
| Mol文件 | 892711-75-0.mol |
| 结构式 |  |
4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺 性质
| 熔点 | 87 - 89°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 溶于DMSO(>25mg/ml) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 供货时可稳定保存 1 年。 DMSO 溶液可在 -20°C 下保存长达 3 个月。 |
| InChI | 1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23) |
| InChIKey | GVGVYDCVFBGALZ-UHFFFAOYSA-N |
| SMILES | CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1 |
| Target | Value |
|
SERCA
() |
CDN1163 (5.5-25 mM; 0-8 hours; rat cardiac myocyte cells) treatment reduces high glucose-induced resistin and nuclear NFATc expression and increases the phosphorylation of AMPKα in a time-dependent manner.
Western Blot Analysis
| Cell Line: | Rat cardiac myocyte cells (H9c2) |
| Concentration: | 5.5 mM, 25 mM |
| Incubation Time: | 0 hour, 4 hours, 8 hours |
| Result: | High glucose-induced resistin and nuclear NFATc expression were significantly reduced. The phosphorylation of AMPKα is increased in a time-dependent manner. |
CDN1163 (50 mg/kg; intraperitoneal injection; for 5 days; male ob/ob mice and lean ob/+ mice) increases SERCA2 Ca 2+ -ATPase activity, decreases endoplasmic reticulum (ER) stress-induced cell death in vitro and improves liver Ca 2+ transport activity. CDN1163 reduces blood glucose levels and improves metabolic parameters and gluconeogenic gene expression, reverses hepatic steatosis, inhibits ER stress and ER stress-induced apoptosis, and improves mitochondrial efficiency in ob/ob mice in vivo.
| Animal Model: | Male 8-10-week old ob/ob mice and lean ob/+ mice |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; for 5 days |
| Result: | Markedly lowered fasting blood glucose, improved glucose tolerance, and ameliorated hepatosteatosis but did not alter glucose levels or body weight. Increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose tissue and reduced the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis, possibly through SERCA2-mediated activation of AMP-activated protein kinase pathway. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S6815 | 4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺 CDN1163 | 892711-75-0 | 5mg | 970.46元 |
| 2026/03/03 | S6815 | 4-异丙氧基-N-(2-甲基喹啉-8-基)苯甲酰胺 CDN1163 | 892711-75-0 | 25mg | 2900.47元 |