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| | 3-(6-BroMopyridin-3-yl)acrylic acid Basic information |
| Product Name: | 3-(6-BroMopyridin-3-yl)acrylic acid | | Synonyms: | (Z/E)-3-(6-bromopyridin-3-yl)acrylic acid;3-(6-bromo-3-pyridinyl)-2-Propenoic acid;3-(6-Bromopyridin-3-yl);3-(6-BroMopyridin-3-yl)acrylic acid;3-(6-BroMopyridin-3-yl)prop-2-enoic acid;(2E)-3-(6-Bromo-3-pyridinyl)acrylic acid;2-Propenoic acid, 3-(6-bromo-3-pyridinyl)- | | CAS: | 1035123-89-7 | | MF: | C8H6BrNO2 | | MW: | 228.04 | | EINECS: | | | Product Categories: | | | Mol File: | 1035123-89-7.mol |  |
| | 3-(6-BroMopyridin-3-yl)acrylic acid Chemical Properties |
| Boiling point | 372.503±27.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.696±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.512±0.10(predicted) | | Appearance | White to off-white Solid |
| | 3-(6-BroMopyridin-3-yl)acrylic acid Usage And Synthesis |
| Synthesis | Step 2: Synthesis of 3-(6-bromopyridin-3-yl)acrylic acid
To a tetrahydrofuran (THF) solution of methyl 3-(6-bromopyridin-3-yl)acrylate (120 mg, 0.495 mmol) was added an aqueous 0.5 N lithium hydroxide (LiOH) solution (2 equiv). The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the resulting residue was dissolved in water (H2O) and washed three times with ether (Et2O). Subsequently, it was neutralized with 1 N hydrochloric acid (HCl) to pH 5~7. The resulting solid was collected by filtration, washed with water and dried under vacuum to afford 3-(6-bromopyridin-3-yl)acrylic acid (100 mg, 88% yield).
1H NMR (300 MHz, DMSO-d6): δ 8.67 (d, 1H, J = 2.1 Hz), 8.11 (dd, 1H, J = 8.4, 2.1 Hz), 7.69 (d, 1H, J = 8.4 Hz), 7.59 (d, 1H, J = 15.9 Hz), 6.71 (d, 1H, J = 15.9 Hz). | | References | [1] Patent: EP1882687, 2008, A1. Location in patent: Page/Page column 27 |
| | 3-(6-BroMopyridin-3-yl)acrylic acid Preparation Products And Raw materials |
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