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| | (2-Thiazolyl)methylamine Basic information |
| | (2-Thiazolyl)methylamine Chemical Properties |
| Melting point | 180-185°C | | Boiling point | 36 °C | | density | 1.204 g/mL at 25 °C | | refractive index | n20/D1.569 | | Fp | 104℃ | | storage temp. | 2-8°C(protect from light) | | pka | 7.24±0.40(Predicted) | | form | liquid | | color | Yellow-green | | InChI | 1S/C4H6N2S/c5-3-4-6-1-2-7-4/h1-2H,3,5H2 | | InChIKey | JOZSYOPADROCMP-UHFFFAOYSA-N | | SMILES | NCc1nccs1 |
| Hazard Codes | Xi,C | | Risk Statements | 22-34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2735PSN1 8 / PGII | | WGK Germany | WGK 3 | | HazardClass | IRRITANT, HYGROSCOPIC, CORROSIVE | | HS Code | 2934100090 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Acute Tox. 4 Oral
Skin Corr. 1B |
| | (2-Thiazolyl)methylamine Usage And Synthesis |
| Chemical Properties | Off-white to cream color solid | | Uses | (2-Thiazolyl)methylamine is a useful compound in the preparation of cephalosporins | | Synthesis | The general procedure for the synthesis of 2-thiazole-methyl-amine from the compound (CAS: 171268-82-9) and water (electrophoretic grade) is as follows:
1. Preparation of GG1 thiazol-2-yl-methylamine azide: triphenylphosphine (2.08 g, 7.9 mmol) was added to a solution of 2-azidomethyl-thiazole (1.11 g, 7.9 mmol) in tetrahydrofuran (THF, 20 mL).
2. Reduction reaction: after 1 h, water (214 μL) and ammonium hydroxide sol (0.5 mL) were added sequentially.
3. Post-treatment: The reaction mixture was stirred overnight and subsequently concentrated under vacuum and purified by fast chromatography (eluent: 5% methanol/dichloromethane) to give the title product 2-thiazolemethanamine as a tan oil (645 mg, 72% yield).
4. The product was characterized by 1H NMR (250 MHz, CDCl3) δ 7.7 (d, 1H, J = 2.0 Hz); 7.25 (d, 1H, J = 2.0 Hz); 4.2 (s, 2H); 1.7 (bs, 2H). | | References | [1] Patent: US5939398, 1999, A
[2] Patent: US5698526, 1997, A |
| | (2-Thiazolyl)methylamine Preparation Products And Raw materials |
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