牛甲状旁腺激活素-(1-34)
| 中文名称 | 牛甲状旁腺激活素-(1-34) |
|---|---|
| 中文同义词 | PHT激活剂(TERIPARATIDE);特立帕肽-多肽原料委托生产;特立帕肽-多肽制剂一致性评价;牛甲状旁腺激素-(1-34);受体激动剂多肽PARATHYROID HORMONE(1-34) BOVINE;牛甲状旁腺激活素-(1-34);PARATHYROID HORMONE (1-34), 牛;L-丙氨酰-L-缬氨酰-L-丝氨酰-L-Α-谷氨酰-L-异亮氨酰-L-谷氨酰胺-L-苯丙氨酰-L-蛋氨酰-L-组氨酰-L-天冬酰胺-L-亮氨酰甘氨酰-L-赖氨酰-L-组氨酰-L-亮氨酰-L-丝氨酰-L-丝氨酰-L-蛋氨酰-L-Α-谷氨酰-L-精氨酰-L-缬氨酰-L-Α-谷氨酰-L-色氨酰-L-亮氨酰-L-精氨酰-L-赖氨酰-L-赖氨酰-L-亮氨酰-L-谷氨酰胺-L-Α-天冬氨酰-L-缬氨酰-L-组氨酰-L-天冬酰胺-L-苯丙氨酸 |
| 英文名称 | PARATHYROID HORMONE (1-34), BOVINE |
| 英文同义词 | ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE;ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE BOVINE;H-ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE-OH;AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF;BPTH 1-34;PTH (1-34) (BOVINE);TERIPARATIDE;PARATHYROID HORMONE (1-34), BOVINE |
| CAS号 | 12583-68-5 |
| 分子式 | C183H288N54O50S2 |
| 分子量 | 4108.71 |
| EINECS号 | 200-001-8 |
| 相关类别 | 多肽;标准品;目录多肽;Neuroscience;Peptide;Hormones;Other Protein/Peptide Hormones;Parathyroid Hormone (PTH)Peptides and Proteins;Parathyroid Hormone Fragments;Peptides for Cell Biology |
| Mol文件 | Mol File |
| 结构式 |
牛甲状旁腺激活素-(1-34) 性质
| 储存条件 | −20°C |
|---|---|
| 溶解度 | DMSO 中≥410.9 mg/mL；水中≥43.8 mg/mL；乙醇中≥64.6 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group.
Cell Proliferation Assay
| Cell Line: | MC3T3-E1 cells |
| Concentration: | 0.1-100 ng/mL |
| Incubation Time: | 2-20 days |
| Result: | Resulted a decrease of osteoblast proliferationin concentration-dependent manner. Resulted in a rebound of proliferation when PTH withdrawal. |
Parathyroid Hormone (1-34)(subcutaneous injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals. Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-P1252 | 牛甲状旁腺激活素-(1-34) Parathyroid Hormone (1-34), bovine | 12583-68-5 | 1 mg | 1100元 |
| 2025/12/22 | HY-P0059 | 牛甲状旁腺激活素-(1-34) Teriparatide | 12583-68-5 | 1mg | 800元 |