- (R)-Epichlorohydrin
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- $10.00
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2026-07-04
- CAS:51594-55-9
- Min. Order: 1kg
- Purity: ≥ 99.5
- Supply Ability: 20 tons
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| | (R)-(-)-Epichlorohydrin Basic information |
| | (R)-(-)-Epichlorohydrin Chemical Properties |
| Melting point | -48°C | | alpha | 34 º (589nm, c=1, MeOH) | | Boiling point | 114 °C(lit.) | | density | 1.180 g/mL at 20 °C(lit.) | | vapor density | 3.29 (vs air) | | vapor pressure | 10 mm Hg ( 16.6 °C) | | refractive index | n20/D 1.438(lit.) | | Fp | 33 °C | | storage temp. | 2-8°C | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Liquid | | color | Clear colorless to very pale yellow | | explosive limit | 21% | | Optical Rotation | [α]20/D 34°, c = 1 in methanol | | Water Solubility | insoluble | | Merck | 14,3532 | | BRN | 1420785 | | InChI | 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2/t3-/m0/s1 | | InChIKey | BRLQWZUYTZBJKN-VKHMYHEASA-N | | SMILES | ClC[C@H]1CO1 | | CAS DataBase Reference | 51594-55-9(CAS DataBase Reference) | | NIST Chemistry Reference | Oxirane, (chloromethyl)-, (R)-(51594-55-9) |
| Hazard Codes | T | | Risk Statements | 45-10-23/24/25-34-43 | | Safety Statements | 53-45 | | RIDADR | UN 2023 6.1/PG 2 | | WGK Germany | 3 | | RTECS | RR0427000 | | Autoignition Temperature | 772 °F | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29103000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Carc. 1B
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
Skin Sens. 1 |
| | (R)-(-)-Epichlorohydrin Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | ((R)-Epichlorohydrin) R-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer. | | Uses | Building block for the synthesis of a key intermediate in the synthesis of stable PGI2 analogue UT-15. | | Definition | ChEBI: (R)-epichlorohydrin is an epichlorohydrin. It is functionally related to a (S)-1,2-epoxypropane. It is an enantiomer of a (S)-epichlorohydrin. | | Pharmaceutical Applications | Chiral epichlorohydrin (ECH) represents a key building block owing to its low molecular weight, simple structure, and high reactivity, serving as a versatile chiral synthon for many pharmaceutical agents, serves as a critical intermediate for the production of l-carnitine, pheromones, and various β-blockers, where its enantiomeric purity directly dictates the efficacy and safety of the final therapeutic products[1]. | | Synthesis | The enzymatic production of (R)-(-)-Epichlorohydrin is predominantly
achieved through the kinetic resolution of racemic mixtures or the
direct dehalogenative cyclization of prochiral substrates, utilizing
epoxide hydrolases or haloalcohol dehalogenases as catalyst. | | References | [1] Wu, K., Lai, Z., Xu, Y., Wu, T., & Mu, X. (2026). Overcoming the concentration-enantioselectivity trade-off in haloalcohol dehalogenase for high-titer (R)-epichlorohydrin production. International Journal of Biological Macromolecules, 358, Article 151790. https://doi.org/10.1016/j.ijbiomac.2026.151790
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| | (R)-(-)-Epichlorohydrin Preparation Products And Raw materials |
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