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| | DIISOPROPYLDICHLOROSILANE Basic information |
| | DIISOPROPYLDICHLOROSILANE Chemical Properties |
| Melting point | <0°C | | Boiling point | 66 °C27 mm Hg(lit.) | | density | 1.026 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.444 | | Fp | 43°C | | storage temp. | Store at room temperature, keep dry and cool | | solubility | sol most organic solvents. | | form | clear liquid | | Specific Gravity | 1.026 | | color | Colorless to Light yellow to Light orange | | Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents | | BRN | 1736244 | | InChI | InChI=1S/C6H14Cl2Si/c1-5(2)9(7,8)6(3)4/h5-6H,1-4H3 | | InChIKey | GSENNYNYEKCQGA-UHFFFAOYSA-N | | SMILES | [Si](Cl)(Cl)(C(C)C)C(C)C | | CAS DataBase Reference | 7751-38-4(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 10-34 | | Safety Statements | 28-36/37/39-45 | | RIDADR | UN 2986 8/PG 2 | | WGK Germany | 3 | | F | 10-21 | | TSCA | No | | HazardClass | 3/8 | | PackingGroup | II | | HS Code | 29319090 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 3
Skin Corr. 1B |
| | DIISOPROPYLDICHLOROSILANE Usage And Synthesis |
| Physical properties | bp 50–55°C/5 mmHg. | | Uses | Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson alkenation reaction.
The use of silicon groups as protection for hydroxy groups has been widely exploited.3 One potentially useful way to protect a nucleoside is by using a protecting group which spans the 3- and 5-hydroxy groups. One of the useful groups which can be used as a bifunctional protecting group in nucleosides is the diisopropylsilyl group. Reaction of the nucleoside with dichlorodiisopropylsilane and imidazole in DMF gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting group is a tetraisopropyldisiloxy group.
 | | Preparation | conveniently prepared by the reaction of diisopropylsilane
in carbon tetrachloride with palladium(II) chloride
at 140°C for 8 h in a steel bomb.Washing the residue with
ether and removing the ether by rotary evaporation yields the
product which is purified by distillation to yield a clear colorless
oil. | | storage | Special care should be used when handling since Dichlorodiisopropylsilane is
corrosive. |
| | DIISOPROPYLDICHLOROSILANE Preparation Products And Raw materials |
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