ICA 110381

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ICA 110381 manufacturers

  • ICA 110381
  • ICA 110381 pictures
  • $71.00
  • 2026-08-01
  • CAS:325457-99-6
  • Purity: 98.00%
  • Supply Ability: 10g
ICA 110381 Basic information
Product Name:ICA 110381
Synonyms:4-Chloro-N-(6-chloro-3-pyridinyl)benzamide;ICA 110381;ICA-11038;4-CHLOR-N-(6-CHLOR-PYRIDIN-3-YL)-BENZAMID;4-Chloro-N-(6-chloro-pyridin-3-yl)-benzamide;ICA 110381; ICA110381;ICA 110381 (Compound 16);inhibit,ICA 110381,Potassium Channel,ICA-110381,KcsA,ICA110381,Inhibitor
CAS:325457-99-6
MF:C12H8Cl2N2O
MW:267.11
EINECS:
Product Categories:
Mol File:325457-99-6.mol
ICA 110381 Structure
ICA 110381 Chemical Properties
Boiling point 336.8±37.0 °C(Predicted)
density 1.440±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO (up to 26 mg/ml) or in Ethanol (up to 5 mg/ml).
form solid
pka11.34±0.70(Predicted)
color White
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
MSDS Information
ICA 110381 Usage And Synthesis
DescriptionICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM).1KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activityin vivo.2
UsesICA 110381 was used to study the pharmacological activities as it selectively activated human KCNQ2 expressed in Chinese hamster ovary, damped neuronal excitability in rat hippocampal CA1 cell and showed anticonvulsant activity in amygdala-kindled rat.
in vivo

ICA 110381 (3-30 mg/kg; p.o.; once) elevates the threshold for induction of afterdischarges and reduced seizure severity and duration in fully amygdala-kindled rats[2].

Animal Model:Female Wistar rats (200-300 g)[2]
Dosage:3 mg/kg, 10 mg/kg and 30 mg/kg (suspended in 0.5% Hydroxyethyl Cellulose (HY-B2221B))
Administration:Oral administration; once
Result:Showed anticonvulsive properties in fully amygdala-kindled rats.
IC 50KV7.1: 0.38 μM (EC50); KV7.3: 0.38 μM (EC50); KV7.1: 15 μM (IC50)
storageStore at +4°C
References[1] GEORGE AMATO. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy[J]. ACS Medicinal Chemistry Letters, 2011, 2 6: 481-484. DOI:10.1021/ml200053x
[2] A BOEHLEN. The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential[J]. British Journal of Pharmacology, 2012, 168 5: 1182-1200. DOI:10.1111/bph.12065
ICA 110381 Preparation Products And Raw materials
Tag:ICA 110381(325457-99-6) Related Product Information
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