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| | A-889425 Basic information |
| Product Name: | A-889425 | | Synonyms: | A-889425;A889425; A 889425;[1(2H),2'-Bipyridine]-4-carboxamide, 3,6-dihydro-3'-methyl-N-[4-[(trifluoromethyl)sulfonyl]phenyl]- | | CAS: | 1072921-02-8 | | MF: | C19H18F3N3O3S | | MW: | 425.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1072921-02-8.mol |  |
| | A-889425 Chemical Properties |
| Boiling point | 614.9±55.0 °C(Predicted) | | density | 1.421±0.06 g/cm3(Predicted) | | pka | 13.03±0.70(Predicted) |
| | A-889425 Usage And Synthesis |
| Uses | A-889425 is an oral active selective TRPV1 receptor antagonist with the with an IC50 of 335 nM (rat) and 34 nM (human). A-889425 has good penetration into the CNS and reduces mechanical allodynia and spinal neuron responses to mechanical stimulation of Complete Freund's adjuvant (HY-153808)-inflamed rat hind paws[1][2]. | | References | [1] McGaraughty S, et al. Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats. J Neurophysiol. 2008;100(6):3158-3166. DOI:10.1152/jn.90768.2008
[2] Brederson JD, et al. TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation. Synapse. 2012;66(3):187-195. DOI:10.1002/syn.20992 |
| | A-889425 Preparation Products And Raw materials |
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