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| | Mes-PEG5- t-butyl ester Basic information |
| Product Name: | Mes-PEG5- t-butyl ester | | Synonyms: | Mes-PEG5- t-butyl ester;MS-PEG5- t-butyl ester;Mes-PEG4-t-butyl ester;CAS_870487-48-2;4,7,10,13,16-Pentaoxa-17-thiaoctadecanoic acid, 1,1-dimethylethyl ester, 17,17-dioxide;3,6,9,12,15-Pentaoxa-2-thiaoctadecan-18-oic acid, 1,1-dimethylethylester, 2,2-dioxide;tert-Butyl 1-(Methylsulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate | | CAS: | 870487-48-2 | | MF: | C16H32O9S | | MW: | 400.48 | | EINECS: | | | Product Categories: | | | Mol File: | 870487-48-2.mol |  |
| | Mes-PEG5- t-butyl ester Chemical Properties |
| Boiling point | 499.9±40.0 °C(Predicted) | | density | 1.147±0.06 g/cm3(Predicted) |
| | Mes-PEG5- t-butyl ester Usage And Synthesis |
| Description | Ms-PEG4-t-butyl ester is a PEG linker with a mesyl group and a t-butyl protecting group. Mesyl is a good leaving group and can participate in substitution reactions. The t-butyl group can be removed under acidic condtions. The hydrophilic PEG linker increases the solubility properties of compounds in aqueous media. | | Uses | Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mes-PEG5- t-butyl ester Preparation Products And Raw materials |
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