Chloroacetamido-PEG4-t-Butyl Ester manufacturers
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| | Chloroacetamido-PEG4-t-Butyl Ester Basic information |
| Product Name: | Chloroacetamido-PEG4-t-Butyl Ester | | Synonyms: | Chloroacetamido-PEG4-t-Butyl Ester;CAS_1365655-90-8;Chloroacetamido-PEG4-C2-Boc;4,7,10,13-Tetraoxa-16-azaoctadecanoic acid, 18-chloro-17-oxo-, 1,1-dimethylethyl ester;tert-Butyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate | | CAS: | 1365655-90-8 | | MF: | C17H32ClNO7 | | MW: | 397.89 | | EINECS: | | | Product Categories: | | | Mol File: | 1365655-90-8.mol |  |
| | Chloroacetamido-PEG4-t-Butyl Ester Chemical Properties |
| Boiling point | 527.6±50.0 °C(Predicted) | | density | 1.119±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Liquid | | pka | 13.57±0.46(Predicted) | | color | Colorless to light yellow |
| | Chloroacetamido-PEG4-t-Butyl Ester Usage And Synthesis |
| Description | Chloroacetamido-PEG4-t-Butyl Ester is a PEG linker containing a chloroacetamide and a t-butyl ester. The chlorine is a good leaving group and can undergo substitution reactions. The t-butyl group is an acid labile protecting group. Upon removal, the carboxylic acid can be further reacted. The hydrophilic PEG chain increases the water solubilty of compounds in aqueous media. | | Uses | Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. | | IC 50 | PEGs; Alkyl/ether | | References | [1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1021/jm2009106 |
| | Chloroacetamido-PEG4-t-Butyl Ester Preparation Products And Raw materials |
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