| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:MitoBloCK-6
CAS:303215-67-0
Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:MitoBloCK-6
CAS:303215-67-0
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol manufacturers
- MitoBloCK-6
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- $47.00
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2026-07-15
- CAS:303215-67-0
- Purity: 99.97%
- Supply Ability: 10g
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| | 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol Basic information |
| Product Name: | 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol | | Synonyms: | 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol;MitoBlock 6;2,4-Dichloro-6-[[[4-(phenylamino)phenyl]imino]methyl]phenol;2,4-dichloro-6-[(E)-{[4-(phenylamino)phenyl]imino}methyl]phenol;Phenol, 2,4-dichloro-6-[[[4-(phenylamino)phenyl]imino]methyl]- | | CAS: | 303215-67-0 | | MF: | C19H14Cl2N2O | | MW: | 357.23 | | EINECS: | | | Product Categories: | | | Mol File: | 303215-67-0.mol | ![2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol Structure](CAS/20180703/GIF/303215-67-0.gif) |
| | 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol Chemical Properties |
| Boiling point | 535.1±50.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | -20°C (des.) | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 6 mg/ml with warming). | | pka | 6.28±0.48(Predicted) | | form | solid | | color | Orange | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol Usage And Synthesis |
| Description | MitoBloCK-6 (303215-67-0) inhibits redox-regulated protein translocation into mitochondria. It attenuates the import of Erv1 substrates by inhibition of Erv1 oxidase activity (the import of Tim23 and AAC was decreased by ~50% at 20 μM). MitoBloCK-6 elucidated an unexpected role for Erv1 in the carrier import pathway, namely transferring substrates from the translocase of the outer membrane complex into the small Tim complexes. It impaired cardiac development in zebrafish embryos and induced apoptosis via the release of cytochrome c in human embryonic stem cells but not differentiated cells.1 | | Uses | MitoBlock-6 is mitochondrial import inhibitor. It inhibits redox-regulated protein translocation into the mitochondria. | | in vivo | MitoBloCK-6 (80 mg/kg, i.p., 5 of 7 days, twice daily) reduces tumor growth and the engraftment of AML cells into the marrow in mice xenografted with OCI-AML2 cells[4].
MitoBloCK-6 (80 mg/kg i.p. 5 of 7 days, 2 weeks) strongly reduces the engraftment of primary AML cells in mice[6].
| | References | [1] DEEPA V DABIR. A small molecule inhibitor of redox-regulated protein translocation into mitochondria.[J]. Developmental cell, 2013, 25 1: 81-92. DOI:10.1016/j.devcel.2013.03.006 |
| | 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol Preparation Products And Raw materials |
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