- UC-1V150
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- $1980.00
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2026-07-27
- CAS:927822-45-5
- Purity:
- Supply Ability: 10g
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| | Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]- Basic information |
| | Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]- Chemical Properties |
| density | 1.406±0.06 g/cm3(Predicted) | | pka | 9.93±0.20(Predicted) |
| | Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]- Usage And Synthesis |
| Uses | UC-1V150 is a specific TLR7 (Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule[1][2]. | | in vivo | UC-1V150 (intravenous injection, 0.38-38 nM, once) effectively induces release of serum cytokines within a certain concentration range in female C57BL/6 mice (5-6 weeks of age)[1].
| Animal Model: | Female C57BL/6 mice (5-6 weeks of age)[1] | | Dosage: | 0.38-38 nM | | Administration: | Intravenous injection; once | | Result: | Induced serum cytokine IL-6 levels about 0.1 ng/mL and IL-2 levels about 1.5 ng/mL at the concentration of 38 nM. |
| | IC 50 | TLR7 | | References | [1] Christina C N Wu, et al. Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3990-5. DOI:10.1073/pnas.0611624104
[2] L N Dahal, et al. UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion. Scand J Immunol. 2018 Jun;87(6):e12666. DOI:10.1111/sji.12666 |
| | Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]- Preparation Products And Raw materials |
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