| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:PF-2545920 (hydrochloride)
Purity:>98% Package:1250RMB/2mg
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
| Products Intro: |
Product Name:PF-2545920 hydrochloride
Purity:>98% HPLC Package:10mg;100mg;1g Remarks:Reagent Grade
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PF-2545920 (hydrochloride) manufacturers
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| | PF-2545920 (hydrochloride) Basic information |
| | PF-2545920 (hydrochloride) Chemical Properties |
| form | Solid | | color | Light brown to brown |
| | PF-2545920 (hydrochloride) Usage And Synthesis |
| Uses | Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect hydrochloride can cross the blood-brain barrier[1][2]. | | in vivo | In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP[2]. | | IC 50 | PDE10 | | References | [1] Wilson JM et al. Phosphodiesterase 10A inhibitor, MP-10 (PF-2545920), produces greater induction of c-Fos in D2 neurons than in D1 neurons in the neostriatum. Neuropharmacology. 2015 Dec;99:379-86. DOI:10.1016/j.neuropharm.2015.08.008
[2] Verhoest PR et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem. 2009 Aug 27;52(16):5188-96. DOI:10.1021/jm900521k |
| | PF-2545920 (hydrochloride) Preparation Products And Raw materials |
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