15-deoxy-Δ12,14-Prostaglandin J2 Glutathione

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15-deoxy-Δ12,14-Prostaglandin J2 Glutathione Basic information
Product Name:15-deoxy-Δ12,14-Prostaglandin J2 Glutathione
Synonyms:15-deoxy-Δ12,14-Prostaglandin J2 Glutathione;PJVSKAKTGJJITI-YPYHUWNQSA-N;Glycine, L-γ-glutamyl-S-[(1S,2R,3E)-2-[(2Z)-6-carboxy-2-hexen-1-yl]-3-(2Z)-2-octen-1-ylidene-4-oxocyclopentyl]-L-cysteinyl-
CAS:537695-15-1
MF:C30H45N3O9S
MW:623.76
EINECS:
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Mol File:537695-15-1.mol
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione Structure
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione Chemical Properties
Boiling point 963.6±65.0 °C(Predicted)
density 1.28±0.1 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 0.2 mg/ml
pka2.21±0.10(Predicted)
Safety Information
MSDS Information
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione Usage And Synthesis
Description15-deoxy-Δ12,14-Prostaglandin J2 Glutathione (15-deoxy-Δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.1,2,3 The biological properties of this compound have not been characterized.
Uses15-deoxy-Δ12,14-Prostaglandin J2 glutathione (15-deoxy-Δ12,14-PGJ2 glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione. The biological properties of this compound have not been characterized.
DefinitionChEBI: 15-deoxy-goyazensolide is a terpene lactone.
References1. Cox, B., Murphey, L.J., Zackert, W.E., et al. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J2, to glutathione Biochim. Biophys. Acta 1584,37-45(2002).
2. Brunoldi, E.M., Zanoni, G., Vidari, G., et al. Cyclopentenone prostaglandin, 15-deoxy-Δ12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione Chem. Res. Toxicol. 20,1528-1535(2007).
3. Paumi, C.M., Smitherman, P.K., Townsend, A.J., et al. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor γ (PPARγ) ligand, 15-deoxy-Δ12,14 prostaglandin J2 (15-d-PGJ2). Biochemistry 43(8),2345-2352(2004).
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione Preparation Products And Raw materials
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