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| | ATI-2341 Basic information |
| Product Name: | ATI-2341 | | Synonyms: | ATI-2341;ATI 2341;ATI2341;L-Leucine, N-(1-oxohexadecyl)-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-α-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-;Palmitoyl-L-methionylglycyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-lysyl-L-leucyl-L-arginyl-L-seryl-L-methionyl-L-threonyl-L-aspartyl-L-lysyl-L-tyrosyl-L-arginyl-L-leucine;ATI-2341 ，S8309 | | CAS: | 1337878-62-2 | | MF: | C104H178N26O25S2 | | MW: | 2256.85 | | EINECS: | | | Product Categories: | | | Mol File: | 1337878-62-2.mol |  |
| | ATI-2341 Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | film | | color | colorless | | Water Solubility | Soluble to 1 mg/ml in water |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | ATI-2341 Usage And Synthesis |
| Biological Activity | ati-2341 is a cxcr4 allosteric agonist.chemokine cxc-type receptor 4 (cxcr4) and its ligand cxcl12 mediate the retention of polymorphonuclear neutrophils and hematopoietic stem and progenitor cells in the bone marrow. drugs disrupting cxcl12-mediated chemoattraction of cxcr4-expressing cells are useful for hematopoietic stem and progenitor cells (hspcs) collection. | | in vitro | ati-2341 could inhibit nkh477-induced camp accumulation in cxcr4-hek cells dose-dependently, but showed no effect in naive hek-293 parental cells. pretreatment of cxcr4- hek cells with pertussis toxin completely abrogated the ability of ati-2341 to inhibit camp accumulation. ati-2341 could also induce a dose-dependent increase in intracellular calcium in cells transfected with wild-type cxcr4 whereas having no effect on untransfected cells. activation of such signaling pathway by ati-2341 was dependent on a fully functional cxcr4 receptor since ati-2341 was not able to mobilize calcium in cells transfected with a cxcr4 receptor variant [1]. | | in vivo | ati-2341 could induce dose-dependent peritoneal recruitment of polymorphonuclear neutrophils (pmns) when i.p. administered to mice. however, when systemically administered by i.v. bolus, ati-2341 acted as an antagonist and could dose-dependently mediate release of pmns from the bone marrow of mice and cynomolgus monkeys. in addition, ati-2341-mediated release of granulocyte/macrophage progenitor cells from the bone marrow was further confirmed by colony-forming assays [1]. | | target | | Target | Value | CXCR4
(in CCRF-CEM cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 194 nM(EC50)
| | IC 50 | 194 nm | | storage | Store at -20°C | | references | [1] tchernychev b et al. discovery of a cxcr4 agonist pepducin that mobilizes bone marrow hematopoietic cells. proc natl acad sci u s a.2010 dec 21;107(51):22255-9. |
| | ATI-2341 Preparation Products And Raw materials |
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